Ebin Thomas , Nimila Elsa Mathews , Kalesh M. Karun
{"title":"Covid 19术后患者的残疾和功能状况--一项基于三级医院的前瞻性研究","authors":"Ebin Thomas , Nimila Elsa Mathews , Kalesh M. Karun","doi":"10.1016/j.cegh.2024.101695","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>The long-term sequelae of COVID-19 infection, the persistence of disability, its temporal profile, and associated factors remain under-documented in South India.</p></div><div><h3>Objectives</h3><p>To estimate the proportion of disability in survivors of COVID-19 at different time points (first, second, and sixth months) and determine the demographic and clinical variables associated with poor functional status which will aid in developing effective treatment and rehabilitation strategies.</p></div><div><h3>Methods</h3><p>A total of 139 COVID-19 patients were interviewed at discharge from a tertiary care hospital and followed up in the first, second, and sixth months. Persistent symptoms and post-COVID functional status (PCFS) scores were recorded at all these time points. Univariate and Multivariate Poisson regression analysis was used to determine the association of socio-demographic variables and other clinical factors with functional status post-COVID-19.</p></div><div><h3>Results</h3><p>48.92 % of patients had complete recovery. However, a majority (51.08 %) experienced persistent functional limitation - 33.81 % had negligible, 15.83 % mild, 0.72 % moderate, and 0.72 % severe limitation. Common symptoms at six months were breathlessness (23.02 %), fatigue (20.14 %), memory loss (10.07 %), myalgia (8.63 %), and post-traumatic stress disorder (7.91 %). Vaccination emerged as a significant predictor of disability status (p < 0.05). Taking two vaccine doses lowered the risk of disability by 0.48 times.</p></div><div><h3>Conclusion</h3><p>At the six-month follow-up of discharged COVID-19 patients, they continue to exhibit persistent functional limitations and symptoms. Administration of two vaccine doses is recommended to improve functional status at six months. Multidisciplinary clinics, telemedicine, and community-based rehabilitation programs are essential to minimize post-COVID-19 functional disability and facilitate complete recovery.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221339842400191X/pdfft?md5=450e865aca361eca0eb3f324184b6710&pid=1-s2.0-S221339842400191X-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Disability and functional status among patients post Covid 19 - A tertiary care hospital based prospective study\",\"authors\":\"Ebin Thomas , Nimila Elsa Mathews , Kalesh M. Karun\",\"doi\":\"10.1016/j.cegh.2024.101695\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>The long-term sequelae of COVID-19 infection, the persistence of disability, its temporal profile, and associated factors remain under-documented in South India.</p></div><div><h3>Objectives</h3><p>To estimate the proportion of disability in survivors of COVID-19 at different time points (first, second, and sixth months) and determine the demographic and clinical variables associated with poor functional status which will aid in developing effective treatment and rehabilitation strategies.</p></div><div><h3>Methods</h3><p>A total of 139 COVID-19 patients were interviewed at discharge from a tertiary care hospital and followed up in the first, second, and sixth months. Persistent symptoms and post-COVID functional status (PCFS) scores were recorded at all these time points. Univariate and Multivariate Poisson regression analysis was used to determine the association of socio-demographic variables and other clinical factors with functional status post-COVID-19.</p></div><div><h3>Results</h3><p>48.92 % of patients had complete recovery. However, a majority (51.08 %) experienced persistent functional limitation - 33.81 % had negligible, 15.83 % mild, 0.72 % moderate, and 0.72 % severe limitation. Common symptoms at six months were breathlessness (23.02 %), fatigue (20.14 %), memory loss (10.07 %), myalgia (8.63 %), and post-traumatic stress disorder (7.91 %). Vaccination emerged as a significant predictor of disability status (p < 0.05). Taking two vaccine doses lowered the risk of disability by 0.48 times.</p></div><div><h3>Conclusion</h3><p>At the six-month follow-up of discharged COVID-19 patients, they continue to exhibit persistent functional limitations and symptoms. Administration of two vaccine doses is recommended to improve functional status at six months. Multidisciplinary clinics, telemedicine, and community-based rehabilitation programs are essential to minimize post-COVID-19 functional disability and facilitate complete recovery.</p></div>\",\"PeriodicalId\":46404,\"journal\":{\"name\":\"Clinical Epidemiology and Global Health\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S221339842400191X/pdfft?md5=450e865aca361eca0eb3f324184b6710&pid=1-s2.0-S221339842400191X-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Epidemiology and Global Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S221339842400191X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Epidemiology and Global Health","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S221339842400191X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Disability and functional status among patients post Covid 19 - A tertiary care hospital based prospective study
Background
The long-term sequelae of COVID-19 infection, the persistence of disability, its temporal profile, and associated factors remain under-documented in South India.
Objectives
To estimate the proportion of disability in survivors of COVID-19 at different time points (first, second, and sixth months) and determine the demographic and clinical variables associated with poor functional status which will aid in developing effective treatment and rehabilitation strategies.
Methods
A total of 139 COVID-19 patients were interviewed at discharge from a tertiary care hospital and followed up in the first, second, and sixth months. Persistent symptoms and post-COVID functional status (PCFS) scores were recorded at all these time points. Univariate and Multivariate Poisson regression analysis was used to determine the association of socio-demographic variables and other clinical factors with functional status post-COVID-19.
Results
48.92 % of patients had complete recovery. However, a majority (51.08 %) experienced persistent functional limitation - 33.81 % had negligible, 15.83 % mild, 0.72 % moderate, and 0.72 % severe limitation. Common symptoms at six months were breathlessness (23.02 %), fatigue (20.14 %), memory loss (10.07 %), myalgia (8.63 %), and post-traumatic stress disorder (7.91 %). Vaccination emerged as a significant predictor of disability status (p < 0.05). Taking two vaccine doses lowered the risk of disability by 0.48 times.
Conclusion
At the six-month follow-up of discharged COVID-19 patients, they continue to exhibit persistent functional limitations and symptoms. Administration of two vaccine doses is recommended to improve functional status at six months. Multidisciplinary clinics, telemedicine, and community-based rehabilitation programs are essential to minimize post-COVID-19 functional disability and facilitate complete recovery.
期刊介绍:
Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.