Hang Yang , Yi Deng , Weizhong Yang , Miaomiao He , Yun Bai
{"title":"具有 GSHOx 拟态活性的 Pd/Ag2S 可通过放大光动力效应来抗感染","authors":"Hang Yang , Yi Deng , Weizhong Yang , Miaomiao He , Yun Bai","doi":"10.1016/j.matlet.2024.136874","DOIUrl":null,"url":null,"abstract":"<div><p>Antibacterial dynamic therapy (ADT) has been a prominent drug-free anti-bacterial approach for treating bacterial infections. Nevertheless, hypoxia and glutathione (GSH) overexpression in the infection microenvironment (IME) limit the therapeutic effect. A Pd/Ag<sub>2</sub>S composite with photothermal characteristics and the capacity to simulate CAT/POD/GSHOx is developed to address this limitation. The CAT/POD/GSHOx-mimetic activities of Pd/Ag<sub>2</sub>S allow the use of H<sub>2</sub>O<sub>2</sub> and the consumption of GSH to enhance photodynamic therapy. <em>In vitro</em> antibacterial experiments demonstrate that Pd/Ag<sub>2</sub>S possesses excellent antimicrobial potential. We construct a new platform capable of modulating the IME to enable synergistic PTT/PDT/CDT therapy for bacterial infections.</p></div>","PeriodicalId":384,"journal":{"name":"Materials Letters","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pd/Ag2S with GSHOx-mimetic activity for anti-infections by amplifying photodynamic effects\",\"authors\":\"Hang Yang , Yi Deng , Weizhong Yang , Miaomiao He , Yun Bai\",\"doi\":\"10.1016/j.matlet.2024.136874\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Antibacterial dynamic therapy (ADT) has been a prominent drug-free anti-bacterial approach for treating bacterial infections. Nevertheless, hypoxia and glutathione (GSH) overexpression in the infection microenvironment (IME) limit the therapeutic effect. A Pd/Ag<sub>2</sub>S composite with photothermal characteristics and the capacity to simulate CAT/POD/GSHOx is developed to address this limitation. The CAT/POD/GSHOx-mimetic activities of Pd/Ag<sub>2</sub>S allow the use of H<sub>2</sub>O<sub>2</sub> and the consumption of GSH to enhance photodynamic therapy. <em>In vitro</em> antibacterial experiments demonstrate that Pd/Ag<sub>2</sub>S possesses excellent antimicrobial potential. We construct a new platform capable of modulating the IME to enable synergistic PTT/PDT/CDT therapy for bacterial infections.</p></div>\",\"PeriodicalId\":384,\"journal\":{\"name\":\"Materials Letters\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-06-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Materials Letters\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0167577X24010139\",\"RegionNum\":4,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Letters","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167577X24010139","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Pd/Ag2S with GSHOx-mimetic activity for anti-infections by amplifying photodynamic effects
Antibacterial dynamic therapy (ADT) has been a prominent drug-free anti-bacterial approach for treating bacterial infections. Nevertheless, hypoxia and glutathione (GSH) overexpression in the infection microenvironment (IME) limit the therapeutic effect. A Pd/Ag2S composite with photothermal characteristics and the capacity to simulate CAT/POD/GSHOx is developed to address this limitation. The CAT/POD/GSHOx-mimetic activities of Pd/Ag2S allow the use of H2O2 and the consumption of GSH to enhance photodynamic therapy. In vitro antibacterial experiments demonstrate that Pd/Ag2S possesses excellent antimicrobial potential. We construct a new platform capable of modulating the IME to enable synergistic PTT/PDT/CDT therapy for bacterial infections.
期刊介绍：
Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials.
Contributions include, but are not limited to, a variety of topics such as:
• Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors
• Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart
• Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction
• Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots.
• Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing.
• Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic
• Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive
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