从香帕夏克山茶花中提取的五种皮马兰二萜及其细胞毒性活性。

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL Journal of Natural Medicines Pub Date : 2024-07-02 DOI:10.1007/s11418-024-01829-8

Kiep Minh Do, Shotaro Hoshino, Takeshi Kodama, Hien Minh Nguyen, Naotaka Ikumi, Hiroyasu Onaka, Hiroyuki Morita

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引用次数: 0

摘要

通过对山奈根茎进行植物化学研究，分离出了五种新的皮马兰二萜，即山奈酚 E-I（1-5）。通过广泛的光谱技术，包括 HR-ESI-MS、UV、IR、1D 和 2D NMR，阐明了 1-5 的结构。1-3 的绝对构型是通过改进的 Mosher 法确定的，4 和 5 的绝对构型是通过 ECD 计算确定的。对所有分离出的化合物针对三种人类癌细胞株（肺癌（A549）、宫颈癌（HeLa）和乳腺癌（MCF-7））进行的进一步细胞毒性检测表明，5 对三种受测细胞株均表现出中等程度的细胞毒性活性，对 A549、HeLa 和 MCF-7 细胞株的 IC50 值分别为 44.78、25.97 和 41.39 Mμ。

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Five pimarane diterpenoids from Kaempferia champasakensis and their cytotoxic activities

A phytochemical investigation of Kaempferia champasakensis rhizomes led to the isolation of five new pimarane diterpenes, kaempferiols E–I (1–5). The structures of 1–5 were elucidated by extensive spectroscopic techniques, including HR-ESI–MS, UV, IR, and 1D and 2D NMR. The absolute configurations of 1–3 were determined by the modified Mosher method, and those of 4 and 5 were established by ECD calculations. Further cytotoxic assay for all isolated compounds against three human cancer cell lines, lung cancer (A549), cervical cancer (HeLa), and breast cancer (MCF-7) indicated that 5 showed moderate cytotoxic activities against the three tested cell lines, with IC₅₀ values of 44.78, 25.97, and 41.39 Mμ for A549, HeLa, and MCF-7 cell lines, respectively.

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来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.