早产儿尿钠浓度与 28 天体重速度：回顾性队列研究

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-07-03 DOI:10.1002/jpen.2668

Natalia Brody MD, Chelsea Oakes MD, Hanwen Huang PhD, Brian K. Stansfield MD

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引用次数: 0

摘要

背景：尿钠浓度被认为是指导早产儿肠内钠补充的标志物；但是，之前没有数据显示尿钠浓度与产后生长之间存在关系：我们对 2010 年 1 月至 2022 年 7 月期间入住佐治亚儿童医院新生儿重症监护室的 224 名早产儿进行了单中心回顾性队列研究。对早产儿的点滴尿钠进行了测量（结果：224 名早产儿的点滴尿钠均高于正常值）：在 224 名早产儿（199 ± 17 天，56% 为男性，71% 为黑人）中，尿钠浓度与出生后 28 周和 36 周的体重速度无关。尿钠浓度与出生时的胎龄关系不大，与 "其他 "早产儿相比，黑人早产儿的尿钠值较高，而白人早产儿的尿钠值较低：结论：出生后第一个月的点尿钠与 DOL 28 周或 PMA 36 周时的体重速度无关。

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Urine sodium concentration and 28-day weight velocity in preterm infants: A retrospective cohort study

Background

Urine sodium concentration has been suggested as a marker to guide enteral sodium supplementation in preterm infants; however, no previous data have demonstrated relationships between urine sodium concentration and postnatal growth.

Methods

We performed a single-center retrospective cohort study on 224 preterm infants admitted to the neonatal intensive care unit at the Children's Hospital of Georgia between January 2010 and July 2022. Spot urine sodium was measured in preterm infants (<34 weeks postmenstrual age [PMA]) between days of life (DOLs) 7 and 28. Our exposure of interest was spot urine sodium concentration (milliequivalents per liter) obtained between postnatal days 7 and 28, and our primary outcome was weight velocity (grams per kilograms per day) determined at DOL 28. Statistical relationships were assessed by multivariate analysis with subgroup comparisons by Student t test and analysis of variance.

Results

In 224 preterm infants (199 ± 17 days, 56% male, 71% Black), urine sodium concentration did not associate with weight velocity at DOL 28 and 36 weeks PMA. Urine sodium concentration was weakly associated with gestational age at birth, and Black preterm infants had higher urine sodium values when compared with “other,” but not White preterm infants.