{"title":"Poster Abstracts","authors":"","doi":"10.1002/jpen.70052","DOIUrl":"10.1002/jpen.70052","url":null,"abstract":"","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"50 S1","pages":"S71-S332"},"PeriodicalIF":4.1,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146121831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Harry M. Vars Award Candidates Abstracts","authors":"","doi":"10.1002/jpen.70046","DOIUrl":"10.1002/jpen.70046","url":null,"abstract":"","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"50 S1","pages":"S63-S70"},"PeriodicalIF":4.1,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nutrition and Metabolism Research Oral Paper Session Abstracts","authors":"","doi":"10.1002/jpen.70047","DOIUrl":"10.1002/jpen.70047","url":null,"abstract":"","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"50 S1","pages":"S5-S62"},"PeriodicalIF":4.1,"publicationDate":"2026-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Georgia Stringer BNut&Diet, Oana A. Tatucu Babet PhD, Graeme Duke MD, Jo Englezos BNut&Diet, Emma J. Ridley PhD
Background
Patients undergoing major upper gastrointestinal surgery are at high nutrition risk, with central or peripheral parenteral nutrition an option when oral or enteral nutrition are not possible. We aimed to determine the number of patients who were indicated but did not receive parenteral nutrition according to an international consensus guideline following major upper gastrointestinal surgery.
Methods
A retrospective audit of patients undergoing major upper gastrointestinal surgery was conducted at a single center between August 13, 2021, and December 29, 2023. Included patients were considered at nutrition risk. Data were extracted on baseline characteristics, nutrition therapy and adequacy of nutrition intake. Data were analyzed using descriptive statistics and were presented as median or mean. The primary outcome was the number of patients who were indicated but did not receive parenteral nutrition according to an international consensus guideline.
Results
A total of 100 patients were included (55 [55%] male; age 68 [59–78] years, and body mass index 25.0 [22.5–29.0] kg/m2). Out of 100 patients, parenteral nutrition was indicated in 42 (42%). Among those who met criteria, 3 of 42 (7%) received parenteral nutrition, whereas 39 of 42 (93%) did not. The percentage of energy and protein adequacy at day 7 was 53 [41–68] % and 58 [39–74] %, respectively.
Conclusions
Most patients who were indicated to did not receive parenteral nutrition within 7 days postsurgery in a single center in Australia. The potential indicators for use of parenteral nutrition via central or peripheral delivery should be further explored.
{"title":"Parenteral nutrition after major elective upper gastrointestinal surgery: A descriptive cohort study","authors":"Georgia Stringer BNut&Diet, Oana A. Tatucu Babet PhD, Graeme Duke MD, Jo Englezos BNut&Diet, Emma J. Ridley PhD","doi":"10.1002/jpen.70040","DOIUrl":"10.1002/jpen.70040","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Patients undergoing major upper gastrointestinal surgery are at high nutrition risk, with central or peripheral parenteral nutrition an option when oral or enteral nutrition are not possible. We aimed to determine the number of patients who were indicated but did not receive parenteral nutrition according to an international consensus guideline following major upper gastrointestinal surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective audit of patients undergoing major upper gastrointestinal surgery was conducted at a single center between August 13, 2021, and December 29, 2023. Included patients were considered at nutrition risk. Data were extracted on baseline characteristics, nutrition therapy and adequacy of nutrition intake. Data were analyzed using descriptive statistics and were presented as median or mean. The primary outcome was the number of patients who were indicated but did not receive parenteral nutrition according to an international consensus guideline.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 100 patients were included (55 [55%] male; age 68 [59–78] years, and body mass index 25.0 [22.5–29.0] kg/m<sup>2</sup>). Out of 100 patients, parenteral nutrition was indicated in 42 (42%). Among those who met criteria, 3 of 42 (7%) received parenteral nutrition, whereas 39 of 42 (93%) did not. The percentage of energy and protein adequacy at day 7 was 53 [41–68] % and 58 [39–74] %, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Most patients who were indicated to did not receive parenteral nutrition within 7 days postsurgery in a single center in Australia. The potential indicators for use of parenteral nutrition via central or peripheral delivery should be further explored.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"50 2","pages":"219-227"},"PeriodicalIF":4.1,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145914405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nora Albanyan PharmD, PhP, Ahmed Ali Alrashed MSc, Jude Howaidi PharmD, Aljawharah Binrokan PharmD, Yahya Mohzari PharmD, PhP, Ahmed AlRassan MSc, Khalid Almagwasi MSc, Dena Alahaideb MSc, Razan Orfali PhD
The integration of electronic health record systems has transformed healthcare by enhancing workflow efficiency, improving data accessibility, and enhancing patient safety. King Fahad Medical City transitioned from a fragmented, paper-based parenteral nutrition management system to a fully integrated Epic electronic health record system, replacing the standalone Baxter ABACUS software. This review outlines a structured approach to integrating automated compounding devices with Epic, incorporating standardized data exchange protocols, interoperability frameworks, development of parenteral nutrition order sets, barcode-enabled verification, and staff training. The clinical decision support system within Epic optimized parenteral nutrition prescription accuracy through real-time alerts, dose limits, and automated calculations. A dedicated parenteral nutrition navigator tool further simplified access to patient data, supporting informed clinical decision-making. This manuscript focuses on the implementation process rather than outcome evaluation. A qualitative approach, using process mapping, training assessments, and end-user feedback, was employed to guide and monitor the integration progress. System refinement and multidisciplinary collaboration resolved challenges, including barcode recognition failures and coding mismatches. This experience underscores the importance of interoperability, decision support tools, and continuous quality improvement in optimizing parenteral nutrition therapy within electronic health record systems, offering a scalable model for healthcare institutions seeking digital transformation.
{"title":"Integration of electronic health records with automated compounding for parenteral nutrition: A narrative review","authors":"Nora Albanyan PharmD, PhP, Ahmed Ali Alrashed MSc, Jude Howaidi PharmD, Aljawharah Binrokan PharmD, Yahya Mohzari PharmD, PhP, Ahmed AlRassan MSc, Khalid Almagwasi MSc, Dena Alahaideb MSc, Razan Orfali PhD","doi":"10.1002/jpen.70045","DOIUrl":"10.1002/jpen.70045","url":null,"abstract":"<p>The integration of electronic health record systems has transformed healthcare by enhancing workflow efficiency, improving data accessibility, and enhancing patient safety. King Fahad Medical City transitioned from a fragmented, paper-based parenteral nutrition management system to a fully integrated Epic electronic health record system, replacing the standalone Baxter ABACUS software. This review outlines a structured approach to integrating automated compounding devices with Epic, incorporating standardized data exchange protocols, interoperability frameworks, development of parenteral nutrition order sets, barcode-enabled verification, and staff training. The clinical decision support system within Epic optimized parenteral nutrition prescription accuracy through real-time alerts, dose limits, and automated calculations. A dedicated parenteral nutrition navigator tool further simplified access to patient data, supporting informed clinical decision-making. This manuscript focuses on the implementation process rather than outcome evaluation. A qualitative approach, using process mapping, training assessments, and end-user feedback, was employed to guide and monitor the integration progress. System refinement and multidisciplinary collaboration resolved challenges, including barcode recognition failures and coding mismatches. This experience underscores the importance of interoperability, decision support tools, and continuous quality improvement in optimizing parenteral nutrition therapy within electronic health record systems, offering a scalable model for healthcare institutions seeking digital transformation.</p>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"50 2","pages":"161-169"},"PeriodicalIF":4.1,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12865769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Introduction to Conference Abstracts","authors":"","doi":"10.1002/jpen.70042","DOIUrl":"10.1002/jpen.70042","url":null,"abstract":"","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"50 S1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lizl Veldsman PhD, RD, Guy A. Richards MD, PhD, Daniel Nel PhD, Tertius A. Kohn PhD, Renée Blaauw PhD, RD
Background
Muscle wasting is a hallmark of critical illness. We evaluated the effect of amino acid supplementation and mobilization on early muscle loss in critically ill patients.
Methods
We conducted a randomized parallel-group trial involving adult patients admitted to the surgical intensive care unit of a tertiary hospital. Participants were randomly assigned to two groups, both receiving standard care nutrition and mobilization. The intervention group also received a daily intravenous amino acid bolus with 45 min of cycle ergometry, starting on days 3–4 for a mean of 6 days. The primary co-outcomes were changes in vastus lateralis myofiber cross-sectional area (from biopsies) and ultrasound-derived rectus femoris cross-sectional area, measured between the preintervention (day 2) and postintervention (day 8) time points. Analyses were conducted using mixed-model analysis of variance and least significant difference testing. Secondary outcomes included the protein-to-DNA ratio, muscle echogenicity, whole-body phase angle, muscle strength (Medical Research Council sum score) and physical capability (6-min walk test).
Results
Fifty patients (90% male, age 37 ± 12 years) were included. Standard of care participants received 1.23 ± 0.18 g/kg/day protein; intervention participants 1.57 ± 0.27 g/kg/day, including 0.37 ± 0.05 g/kg/day from the supplement. Muscle loss occurred significantly over time (biopsy P = 0.01; ultrasound P < 0.001), with no significant differences between groups. Similarly, no significant differences were observed in protein-to-DNA ratio, muscle echogenicity, phase angle, muscle strength, or physical capability.
Conclusion
A short-duration combined intervention of intravenous bolus amino acids and cycle ergometry, limited to the acute phase of critical illness, did not reduce muscle loss or improve muscle quality, strength, or physical capability.
{"title":"Combined intravenous bolus amino acid supplementation and mobilization on early muscle loss in critically ill adults: A randomized controlled trial","authors":"Lizl Veldsman PhD, RD, Guy A. Richards MD, PhD, Daniel Nel PhD, Tertius A. Kohn PhD, Renée Blaauw PhD, RD","doi":"10.1002/jpen.70041","DOIUrl":"10.1002/jpen.70041","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Muscle wasting is a hallmark of critical illness. We evaluated the effect of amino acid supplementation and mobilization on early muscle loss in critically ill patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a randomized parallel-group trial involving adult patients admitted to the surgical intensive care unit of a tertiary hospital. Participants were randomly assigned to two groups, both receiving standard care nutrition and mobilization. The intervention group also received a daily intravenous amino acid bolus with 45 min of cycle ergometry, starting on days 3–4 for a mean of 6 days. The primary co-outcomes were changes in vastus lateralis myofiber cross-sectional area (from biopsies) and ultrasound-derived rectus femoris cross-sectional area, measured between the preintervention (day 2) and postintervention (day 8) time points. Analyses were conducted using mixed-model analysis of variance and least significant difference testing. Secondary outcomes included the protein-to-DNA ratio, muscle echogenicity, whole-body phase angle, muscle strength (Medical Research Council sum score) and physical capability (6-min walk test).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifty patients (90% male, age 37 ± 12 years) were included. Standard of care participants received 1.23 ± 0.18 g/kg/day protein; intervention participants 1.57 ± 0.27 g/kg/day, including 0.37 ± 0.05 g/kg/day from the supplement. Muscle loss occurred significantly over time (biopsy <i>P</i> = 0.01; ultrasound <i>P</i> < 0.001), with no significant differences between groups. Similarly, no significant differences were observed in protein-to-DNA ratio, muscle echogenicity, phase angle, muscle strength, or physical capability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>A short-duration combined intervention of intravenous bolus amino acids and cycle ergometry, limited to the acute phase of critical illness, did not reduce muscle loss or improve muscle quality, strength, or physical capability.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"50 2","pages":"170-182"},"PeriodicalIF":4.1,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12865756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145867148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patients with visceral obesity experience an amplified systemic inflammatory response during the perioperative period, increasing infection risk. Significant skeletal muscle loss following invasive cardiovascular surgery presents a considerable clinical challenge. This study aimed to investigate the association between preoperative visceral fat mass and postoperative skeletal muscle loss, emphasizing the clinical utility of computed tomography–based body composition analysis.
Methods
This retrospective cohort study included Japanese patients who underwent elective cardiovascular surgery (May 2020 to December 2023). Preoperative computed tomography was used to calculate the visceral fat area, subcutaneous fat area, and psoas muscle area as indicators of skeletal muscle mass. Skeletal muscle loss was assessed by the change in the psoas muscle area between the preoperative period and the first postoperative week.
Results
Of the 159 patients included in the final analysis, 69.2% were classified as having visceral obesity. Preoperative visceral fat area was significantly correlated with peak postoperative C-reactive protein (CRP) levels (r = 0.361) and changes in psoas muscle area (r = −0.374), whereas subcutaneous fat area showed no such correlation. In the multivariate logistic regression analysis, after adjusting for clinical characteristics, including age, body mass index, operative time, preoperative CRP level, EuroSCORE II, and preoperative 6-min walk distance, higher visceral fat area was significantly associated with postoperative skeletal muscle loss (odds ratio [OR]: 1.01; 95% CI: 1.00–1.02), whereas subcutaneous fat area was not (OR: 1.01; 95% CI: 0.99–1.02).
Conclusions
Preoperative visceral fat area measured using computed tomography is a robust predictor of postoperative skeletal muscle loss. Visceral obesity, linked to heightened systemic inflammation, may accelerate muscle degradation through proinflammatory pathways.
{"title":"Preoperative visceral fat and muscle loss after cardiovascular surgery: A retrospective cohort study","authors":"Kazuya Shimizu PT, MS, Ryota Matsuzawa PT, PhD, Shinya Nakamura PT, BS, Hiroyuki Miyoshi PT, BS, Keita Murakawa PT, MS, Hideo Kawakami MD, PhD, Ryohei Mineo MD, Yasuko Gotake MD, Motoaki Ohnaka MD, PhD, Masamichi Matsumori MD, PhD, Akira Tamaki PT, PhD","doi":"10.1002/jpen.70039","DOIUrl":"10.1002/jpen.70039","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Patients with visceral obesity experience an amplified systemic inflammatory response during the perioperative period, increasing infection risk. Significant skeletal muscle loss following invasive cardiovascular surgery presents a considerable clinical challenge. This study aimed to investigate the association between preoperative visceral fat mass and postoperative skeletal muscle loss, emphasizing the clinical utility of computed tomography–based body composition analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study included Japanese patients who underwent elective cardiovascular surgery (May 2020 to December 2023). Preoperative computed tomography was used to calculate the visceral fat area, subcutaneous fat area, and psoas muscle area as indicators of skeletal muscle mass. Skeletal muscle loss was assessed by the change in the psoas muscle area between the preoperative period and the first postoperative week.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 159 patients included in the final analysis, 69.2% were classified as having visceral obesity. Preoperative visceral fat area was significantly correlated with peak postoperative <i>C</i>-reactive protein (CRP) levels (<i>r</i> = 0.361) and changes in psoas muscle area (<i>r</i> = −0.374), whereas subcutaneous fat area showed no such correlation. In the multivariate logistic regression analysis, after adjusting for clinical characteristics, including age, body mass index, operative time, preoperative CRP level, EuroSCORE II, and preoperative 6-min walk distance, higher visceral fat area was significantly associated with postoperative skeletal muscle loss (odds ratio [OR]: 1.01; 95% CI: 1.00–1.02), whereas subcutaneous fat area was not (OR: 1.01; 95% CI: 0.99–1.02).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Preoperative visceral fat area measured using computed tomography is a robust predictor of postoperative skeletal muscle loss. Visceral obesity, linked to heightened systemic inflammation, may accelerate muscle degradation through proinflammatory pathways.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"50 2","pages":"192-201"},"PeriodicalIF":4.1,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12865746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145777168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vito D'Andrea MD, Giorgia Prontera MD, Cecilia Monachini MD, Micaela Cerreti MD, Francesca Baldo MD, Giovanni Barone MD, Giovanni Vento
Background
Heparin is frequently infused in neonatal central venous catheters to prevent occlusion during parenteral nutrition despite limited evidence of its effectiveness and potential safety concerns in preterm infants. This study evaluated the incidence of catheter occlusion in epicutaneo-caval catheters managed without heparin in a large neonatal cohort.
Methods
We conducted a descriptive cohort study including all neonates admitted to the neonatal intensive care unit who required epicutaneo-caval catheters placement for parenteral nutrition. No heparin was added to infusions. Data were collected on catheter characteristics, insertion parameters, and reasons for removal. The primary outcome was the incidence of catheter occlusion per 1000 catheter-days.
Results
A total of 357 neonates with 357 epicutaneo-caval catheters were analyzed, representing 4007 catheter-days. Mean ± SD gestational age was 29 ± 4.1 weeks, and mean ± SD birthweight was 1050 ± 797 g. The mean ± SD catheter dwell time was 11.2 ± 7.7 days. Most catheter insertions occurred in the upper extremities (92.7%), with prematurity being the most common indication (53.7%). Catheter removal was elective in 67.5% of cases. Only three occlusions were reported, corresponding to 0.7% of catheters and 0.76 occlusions per 1000 catheter-days.
Conclusion
This study demonstrates a low rate of epicutaneo-caval catheters occlusion in neonates receiving parenteral nutrition without heparin infusion. These findings support the safety and feasibility of a heparin-free approach in neonatal central catheter management when standardized care protocols are followed.
{"title":"Epicutaneo-caval catheter occlusion in neonates without heparin infusion during parenteral nutrition: A descriptive cohort study","authors":"Vito D'Andrea MD, Giorgia Prontera MD, Cecilia Monachini MD, Micaela Cerreti MD, Francesca Baldo MD, Giovanni Barone MD, Giovanni Vento","doi":"10.1002/jpen.70037","DOIUrl":"10.1002/jpen.70037","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Heparin is frequently infused in neonatal central venous catheters to prevent occlusion during parenteral nutrition despite limited evidence of its effectiveness and potential safety concerns in preterm infants. This study evaluated the incidence of catheter occlusion in epicutaneo-caval catheters managed without heparin in a large neonatal cohort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a descriptive cohort study including all neonates admitted to the neonatal intensive care unit who required epicutaneo-caval catheters placement for parenteral nutrition. No heparin was added to infusions. Data were collected on catheter characteristics, insertion parameters, and reasons for removal. The primary outcome was the incidence of catheter occlusion per 1000 catheter-days.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 357 neonates with 357 epicutaneo-caval catheters were analyzed, representing 4007 catheter-days. Mean ± SD gestational age was 29 ± 4.1 weeks, and mean ± SD birthweight was 1050 ± 797 g. The mean ± SD catheter dwell time was 11.2 ± 7.7 days. Most catheter insertions occurred in the upper extremities (92.7%), with prematurity being the most common indication (53.7%). Catheter removal was elective in 67.5% of cases. Only three occlusions were reported, corresponding to 0.7% of catheters and 0.76 occlusions per 1000 catheter-days.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study demonstrates a low rate of epicutaneo-caval catheters occlusion in neonates receiving parenteral nutrition without heparin infusion. These findings support the safety and feasibility of a heparin-free approach in neonatal central catheter management when standardized care protocols are followed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"50 2","pages":"247-251"},"PeriodicalIF":4.1,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12865733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145746549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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