对卵母细胞胞质晶格相关蛋白的新认识。

IF 13.6 2区 生物学 Q1 GENETICS & HEREDITY Trends in Genetics Pub Date : 2024-10-01 Epub Date: 2024-07-01 DOI:10.1016/j.tig.2024.06.002
Carlo Giaccari, Francesco Cecere, Lucia Argenziano, Angela Pagano, Andrea Riccio
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引用次数: 0

摘要

卵母细胞成熟和植入前胚胎发育对成功妊娠以及正确建立和维持基因组印记至关重要。细胞质晶格(CPLs)是哺乳动物卵母细胞和植入前胚胎细胞质中高度丰富的结构,借助新技术以及对人类患者和小鼠模型进行的全息研究,与细胞质晶格相关的蛋白质在母体向胚胎过渡过程中的重要性正变得越来越明显。本综述重点介绍了最近发现的这些蛋白质在蛋白质储存和其他卵母细胞胞质过程、表观遗传重编程以及子代基因组激活(ZGA)中的作用。更好地理解这些事件可能会大大改善临床诊断,并为旨在纠正或减轻女性生育问题和基因组印记紊乱的针对性干预措施铺平道路。
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New insights into oocyte cytoplasmic lattice-associated proteins.

Oocyte maturation and preimplantation embryo development are critical to successful pregnancy outcomes and the correct establishment and maintenance of genomic imprinting. Thanks to novel technologies and omics studies in human patients and mouse models, the importance of the proteins associated with the cytoplasmic lattices (CPLs), highly abundant structures found in the cytoplasm of mammalian oocytes and preimplantation embryos, in the maternal to zygotic transition is becoming increasingly evident. This review highlights the recent discoveries on the role of these proteins in protein storage and other oocyte cytoplasmic processes, epigenetic reprogramming, and zygotic genome activation (ZGA). A better comprehension of these events may significantly improve clinical diagnosis and pave the way for targeted interventions aiming to correct or mitigate female fertility issues and genomic imprinting disorders.

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来源期刊
Trends in Genetics
Trends in Genetics 生物-遗传学
CiteScore
20.90
自引率
0.90%
发文量
160
审稿时长
6-12 weeks
期刊介绍: Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology. Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.
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