Zuzana Simova, Michal Sima, Daniela Pelclova, Pavlina Klusackova, Vladimir Zdimal, Jaroslav Schwarz, Ludmila Maskova, Pavel Bradna, Adela Roubickova, Zdenek Krejcik, Jiri Klema, Pavel Rossner, Andrea Rossnerova
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Transcriptome changes in humans acutely exposed to nanoparticles during grinding of dental nanocomposites.
Aim: Today, there is a lack of research studies concerning human acute exposure to nanoparticles (NPs). Our investigation aimed to simulate real-world acute inhalation exposure to NPs released during work with dental nanocomposites in a dental office or technician laboratory. Methods: Blood samples from female volunteers were processed before and after inhalation exposure. Transcriptomic mRNA and miRNA expression changes were analyzed. Results: We detected large interindividual variability, 90 significantly deregulated mRNAs, and 4 miRNAs when samples of participants before and after dental nanocomposite grinding were compared. Conclusion: The results suggest that inhaled dental NPs may present an occupational hazard to human health, as indicated by the changes in the processes related to oxidative stress, synthesis of eicosanoids, and cell division.
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