Imkongyanger, Kikoleho Richa, Tsenbeni N Lotha, Ketiyala Ao, Lemzila Rudithongru, Vevosa Nakro, Vimha Ritse, Nima D Namsa, Pranay Punj Pankaj, Upasana Bora Sinha, Latonglila Jamir
{"title":"胍类衍生物的可持续合成及其抗糖尿病功效的计算评估。","authors":"Imkongyanger, Kikoleho Richa, Tsenbeni N Lotha, Ketiyala Ao, Lemzila Rudithongru, Vevosa Nakro, Vimha Ritse, Nima D Namsa, Pranay Punj Pankaj, Upasana Bora Sinha, Latonglila Jamir","doi":"10.2174/0118715303287962240621053459","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Type 2 Diabetes Mellitus (T2DM) represents a significant and pressing worldwide health concern, necessitating the quest for enhanced antidiabetic pharmaceuticals. Guanidine derivatives, notably metformin and buformin, have emerged as pivotal therapeutic agents for T2DM management.</p><p><strong>Aims: </strong>The present study introduces an efficient one-pot synthesis method for the production of symmetrical guanidine compounds.</p><p><strong>Methods: </strong>This synthesis involves the reaction of isothiocyanates with secondary amines, employing an environmentally friendly and recyclable reagent, tetrabutylphosphonium tribromide (TBPTB).</p><p><strong>Results: </strong>A comprehensive assessment of the biological activity of the synthesized guanidine compounds, specifically in the context of T2DM, has been rigorously conducted.</p><p><strong>Conclusion: </strong>Additionally, computational analyses have unveiled their substantial potential as promising antidiabetic agents. Results highlight the relevance of these compounds in the ongoing pursuit of novel therapeutic solutions for T2DM.</p>.</p>","PeriodicalId":94316,"journal":{"name":"Endocrine, metabolic & immune disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sustainable Synthesis of Guanidine Derivatives and Computational Assessment of their Antidiabetic Efficacy.\",\"authors\":\"Imkongyanger, Kikoleho Richa, Tsenbeni N Lotha, Ketiyala Ao, Lemzila Rudithongru, Vevosa Nakro, Vimha Ritse, Nima D Namsa, Pranay Punj Pankaj, Upasana Bora Sinha, Latonglila Jamir\",\"doi\":\"10.2174/0118715303287962240621053459\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Type 2 Diabetes Mellitus (T2DM) represents a significant and pressing worldwide health concern, necessitating the quest for enhanced antidiabetic pharmaceuticals. Guanidine derivatives, notably metformin and buformin, have emerged as pivotal therapeutic agents for T2DM management.</p><p><strong>Aims: </strong>The present study introduces an efficient one-pot synthesis method for the production of symmetrical guanidine compounds.</p><p><strong>Methods: </strong>This synthesis involves the reaction of isothiocyanates with secondary amines, employing an environmentally friendly and recyclable reagent, tetrabutylphosphonium tribromide (TBPTB).</p><p><strong>Results: </strong>A comprehensive assessment of the biological activity of the synthesized guanidine compounds, specifically in the context of T2DM, has been rigorously conducted.</p><p><strong>Conclusion: </strong>Additionally, computational analyses have unveiled their substantial potential as promising antidiabetic agents. Results highlight the relevance of these compounds in the ongoing pursuit of novel therapeutic solutions for T2DM.</p>.</p>\",\"PeriodicalId\":94316,\"journal\":{\"name\":\"Endocrine, metabolic & immune disorders drug targets\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrine, metabolic & immune disorders drug targets\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/0118715303287962240621053459\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine, metabolic & immune disorders drug targets","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0118715303287962240621053459","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Sustainable Synthesis of Guanidine Derivatives and Computational Assessment of their Antidiabetic Efficacy.
Background: Type 2 Diabetes Mellitus (T2DM) represents a significant and pressing worldwide health concern, necessitating the quest for enhanced antidiabetic pharmaceuticals. Guanidine derivatives, notably metformin and buformin, have emerged as pivotal therapeutic agents for T2DM management.
Aims: The present study introduces an efficient one-pot synthesis method for the production of symmetrical guanidine compounds.
Methods: This synthesis involves the reaction of isothiocyanates with secondary amines, employing an environmentally friendly and recyclable reagent, tetrabutylphosphonium tribromide (TBPTB).
Results: A comprehensive assessment of the biological activity of the synthesized guanidine compounds, specifically in the context of T2DM, has been rigorously conducted.
Conclusion: Additionally, computational analyses have unveiled their substantial potential as promising antidiabetic agents. Results highlight the relevance of these compounds in the ongoing pursuit of novel therapeutic solutions for T2DM.
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