跟踪过氧物酶体

IF 5.9 3区 农林科学 Q1 VETERINARY SCIENCES Lab Animal Pub Date : 2024-07-02 DOI:10.1038/s41684-024-01398-z
Alexandra Le Bras
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引用次数: 0

摘要

过氧物酶体是膜结合细胞器,对脂质代谢和氧化还原平衡至关重要。这些细胞器对人类健康和发育的重要性因几种遗传性疾病(即所谓的过氧化物酶体疾病)的存在而得到强调。现有的动物模型和患者样本过氧化物酶体成像方法不适合研究过氧化物酶体功能障碍和过氧化物酶体生物发生异常,阻碍了研究进展。发表在《自然-通讯》(Nature Communications)上的一项研究报告了一种基于荧光脂肪酸探针对活哺乳动物细胞和斑马鱼胚胎中的功能性过氧物酶体和功能障碍过氧物酶体进行染色的新技术。BODIPY-C12 探针被广泛用于追踪积聚在脂滴和线粒体中的脂质,研究人员对这种探针进行了改良,创造出了过氧物酶体特异性探针 PeroxiSPY650 和 PeroxiSPY555。他们的研究表明,这些探针集高过氧化物酶体特异性、红色和远红光谱的明亮荧光以及快速无细胞毒性染色于一身,适用于活人体细胞和斑马鱼胚胎的过氧化物酶体成像:Korotkova, D. et al.Nat.15, 4314 (2024)
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Tracking peroxisomes
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来源期刊
Lab Animal
Lab Animal 农林科学-兽医学
CiteScore
0.60
自引率
2.90%
发文量
181
审稿时长
>36 weeks
期刊介绍: LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research. LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.
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