Yuejun Jiang, Cong Xu, Yunshi Li, Hong Wang, Lu Liu, Yicheng Ye, Junbin Gao, Hao Tian, Fei Peng, Yingfeng Tu, Yingjia Li
{"title":"瓶式纳米马达可放大肿瘤氧化应激,从而增强钙超载/化学动力学疗法。","authors":"Yuejun Jiang, Cong Xu, Yunshi Li, Hong Wang, Lu Liu, Yicheng Ye, Junbin Gao, Hao Tian, Fei Peng, Yingfeng Tu, Yingjia Li","doi":"10.1002/smll.202404402","DOIUrl":null,"url":null,"abstract":"<p><p>Developing multifunctional, stimuli-responsive nanomedicine is intriguing because it has the potential to effectively treat cancer. Yet, poor tumor penetration of nanodrugs results in limited antitumor efficacy. Herein, an oxygen-driven silicon-based nanomotor (Si-motor) loaded with MnO and CaO<sub>2</sub> nanoparticles is developed, which can move in tumor microenvironment (TME) by the cascade reaction of CaO<sub>2</sub> and MnO. Under acidic TME, CaO<sub>2</sub> reacts with acid to release Ca<sup>2+</sup> to induce mitochondrial damage and simultaneously produces O<sub>2</sub> and H<sub>2</sub>O<sub>2</sub>, when the loaded MnO exerts Fenton-like activity to produce ·OH and O<sub>2</sub> based on the produced H<sub>2</sub>O<sub>2</sub>. The generated O<sub>2</sub> drives Si-motor forward, thus endowing active delivery capability of the formed motors in TME. Meanwhile, MnO with glutathione (GSH) depletion ability further prevents reactive oxygen species (ROS) from being destroyed. Such TME actuated Si-motor with enhanced cellular uptake and deep penetration provides amplification of synergistic oxidative stresscaused by intracellular Ca<sup>2 +</sup> overloading, GSH depletion induced by Mn<sup>2+</sup>, and Mn<sup>2+</sup> mediated chemodynamic treatment (CDT), leading to excellent tumor cell death. The created nanomotor may offer an effective platform for active synergistic cancer treatment.</p>","PeriodicalId":228,"journal":{"name":"Small","volume":null,"pages":null},"PeriodicalIF":13.0000,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Bottle Nanomotors Amplify Tumor Oxidative Stress for Enhanced Calcium Overload/Chemodynamic Therapy.\",\"authors\":\"Yuejun Jiang, Cong Xu, Yunshi Li, Hong Wang, Lu Liu, Yicheng Ye, Junbin Gao, Hao Tian, Fei Peng, Yingfeng Tu, Yingjia Li\",\"doi\":\"10.1002/smll.202404402\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Developing multifunctional, stimuli-responsive nanomedicine is intriguing because it has the potential to effectively treat cancer. Yet, poor tumor penetration of nanodrugs results in limited antitumor efficacy. Herein, an oxygen-driven silicon-based nanomotor (Si-motor) loaded with MnO and CaO<sub>2</sub> nanoparticles is developed, which can move in tumor microenvironment (TME) by the cascade reaction of CaO<sub>2</sub> and MnO. Under acidic TME, CaO<sub>2</sub> reacts with acid to release Ca<sup>2+</sup> to induce mitochondrial damage and simultaneously produces O<sub>2</sub> and H<sub>2</sub>O<sub>2</sub>, when the loaded MnO exerts Fenton-like activity to produce ·OH and O<sub>2</sub> based on the produced H<sub>2</sub>O<sub>2</sub>. The generated O<sub>2</sub> drives Si-motor forward, thus endowing active delivery capability of the formed motors in TME. Meanwhile, MnO with glutathione (GSH) depletion ability further prevents reactive oxygen species (ROS) from being destroyed. Such TME actuated Si-motor with enhanced cellular uptake and deep penetration provides amplification of synergistic oxidative stresscaused by intracellular Ca<sup>2 +</sup> overloading, GSH depletion induced by Mn<sup>2+</sup>, and Mn<sup>2+</sup> mediated chemodynamic treatment (CDT), leading to excellent tumor cell death. The created nanomotor may offer an effective platform for active synergistic cancer treatment.</p>\",\"PeriodicalId\":228,\"journal\":{\"name\":\"Small\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":13.0000,\"publicationDate\":\"2024-07-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Small\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1002/smll.202404402\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Small","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1002/smll.202404402","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Developing multifunctional, stimuli-responsive nanomedicine is intriguing because it has the potential to effectively treat cancer. Yet, poor tumor penetration of nanodrugs results in limited antitumor efficacy. Herein, an oxygen-driven silicon-based nanomotor (Si-motor) loaded with MnO and CaO2 nanoparticles is developed, which can move in tumor microenvironment (TME) by the cascade reaction of CaO2 and MnO. Under acidic TME, CaO2 reacts with acid to release Ca2+ to induce mitochondrial damage and simultaneously produces O2 and H2O2, when the loaded MnO exerts Fenton-like activity to produce ·OH and O2 based on the produced H2O2. The generated O2 drives Si-motor forward, thus endowing active delivery capability of the formed motors in TME. Meanwhile, MnO with glutathione (GSH) depletion ability further prevents reactive oxygen species (ROS) from being destroyed. Such TME actuated Si-motor with enhanced cellular uptake and deep penetration provides amplification of synergistic oxidative stresscaused by intracellular Ca2 + overloading, GSH depletion induced by Mn2+, and Mn2+ mediated chemodynamic treatment (CDT), leading to excellent tumor cell death. The created nanomotor may offer an effective platform for active synergistic cancer treatment.
期刊介绍:
Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments.
With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology.
Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.