在可见光诱导反应下合成含氧和含硫杂环及其衍生物的最新进展。

IF 2.9 4区 医学 Q3 CHEMISTRY, MEDICINAL Current topics in medicinal chemistry Pub Date : 2024-07-03 DOI:10.2174/0115680266313243240624071549
Tubai Ghosh, Sougata Santra, Grigory V Zyryanov, Brindaban C Ranu
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引用次数: 0

摘要

近来,以可见光为媒介的反应已成为在温和的反应条件下合成各种有机分子的有力策略。反应通常在室温下进行,因此敏感的官能团不会受到影响。因此,这种方法受到了学术界和工业界的强烈关注。一般来说,杂环化合物因其生物活性和在治疗学中的应用而备受关注。最近,含氧和含硫杂环化合物引起了人们的关注,因为这些化合物在抗癌药物、抗生素、抗真菌剂和抗炎剂等方面的应用前景广阔。通过高效、绿色的路线合成这类化合物已成为一个重要目标。本综述重点介绍了在可见光诱导反应下合成这类化合物及其衍生物的各种方法。文中还讨论了每种方法的绿色方面和机理。
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Recent Developments on the Synthesis of Oxygen- and Sulfur-containing Heterocycles and their Derivatives under Visible Light Induced Reactions.

Visible-light-mediated reactions have recently emerged as a powerful strategy for the synthesis of diverse organic molecules under mild reaction conditions. Usually, the reactions are performed at room temperature and thus sensitive functional groups remain unaffected. Thus, this protocol has received intense interest from academia as well as industries. The heterocycles, in general, are of much interest because of their biological activities and application in therapeutics. The Oxygen- and Sulfur-containing heterocyclic compounds have recently attracted attention as these compounds showed promising activities as anti-cancer drugs, antibiotics, antifungal and anti-inflammatory agents among other applications. The synthesis of this class of compounds by efficient and greener routes has become an important target. This review highlights the various procedures for the synthesis of these compounds and their derivatives under visible light-induced reactions. The green aspects and mechanism of each procedure have been discussed.

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来源期刊
CiteScore
6.40
自引率
2.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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