从莬丝子中发现具有抗炎作用的倍半萜内酯

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED Journal of Asian Natural Products Research Pub Date : 2024-07-04 DOI:10.1080/10286020.2024.2370401

Xian-Sheng Ye, Kuan Lin, Chang-Long Leng, Yu-Ran Gui, Shu-Xiu Zhu, Hui-Ying Liu, Yi-Yuan Xia, Bin-Lian Sun, Wei Liu, Xi-Ji Shu

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引用次数: 0

摘要

初步研究发现，莬丝子乙酸乙酯洗脱液（YJ-E）可抑制 LPS 刺激的 BV2 细胞中 p-p65、p-IκBα、p-IKKα/β 和 p-AKT 等关键蛋白的表达。通过进一步的植物化学研究，从 YJ-E 中分离出了八种化合物，其中包括一种新的倍半萜内酯。通过一些光谱数据以及与已知化合物核磁共振数据的比较，阐明了这些化合物的结构。此外，还对所有分离物的抗炎效果进行了评估。结果表明，化合物 3 和 4 分别明显减轻了 LPS 刺激的 BV2 细胞中 p-IκBα、p-p65 和 p-AKT 的表达。

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Discovery of sesquiterpene lactones with anti-inflammatory effect from Youngia japonica.

The preliminary study revealed that the ethyl acetate eluate of Youngia japonica (YJ-E) could inhibit the expression of key proteins of p-p65, p-IκBα, p-IKKα/β, and p-AKT in LPS stimulated BV2 cell. Further phytochemical study led to the isolation of eight compounds from YJ-E, including one new sesquiterpene lactone. Their structures were elucidated by several spectroscopic data, and comparing the NMR data of known compound. In addition, all of the isolates were evaluated for the anti-inflammatory effect. As a result, compounds 3 and 4 distinctly attenuated the expressions of p-IκBα, p-p65, and p-AKT in LPS stimulated BV2 cell, respectively.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.