治疗糖尿病的植物药方法:概述经科学证实具有降血糖作用的药用植物及其可能的作用机制

IF 7.3 2区 生物学 Q1 PLANT SCIENCES Phytochemistry Reviews Pub Date : 2024-06-22 DOI:10.1007/s11101-024-09984-2
Stanley I. R. Okoduwa, Daniel H. Mhya, Ibrahim Abdulwaliyu, Bernard E. Igiri, Ugochi J. Okoduwa, David E. Arthur, Aderinsola O. Laleye, Gerrard J. Osang, Oluwatimilehin L. Onaleye, Emmanuella Nathyns-Pepple
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引用次数: 0

摘要

糖尿病是一种代谢性疾病,可导致影响心脏、肾脏和眼睛的各种并发症。一些合成和天然产品已被用于疾病的治疗,但该疾病仍然是一个全球性的挑战。使用植物作为糖尿病的替代治疗方法的情况一直在增加。遗憾的是,目前还没有一个全面的资料库来指导未来在具有相关作用机制的植物领域的研究,以开发有效的药物。目的:确定并汇编经科学证明具有降血糖特性的常用药用植物及其可能的作用模式。为此,我们使用 DOAJ、EMBASE、Europe PMC、FSTA、Google Scholar、HubMed、Indian Citation Index、Medline Plus、Merck Index、PubMed、ScienceDirect、Science3open、Science Open、SciFinder、Scirus、Core、Scopus、Semantic Scholar、Shodhganga 和 World Wide Science 等检索工具对科学数据库进行了文献检索。搜索关键词包括:药用植物、抗糖尿病药、降血糖药、α-淀粉酶/葡萄糖苷酶抑制、葡萄糖代谢酶、抗高血糖、胰岛素分泌/替代物、β-细胞改善、植物化学物质、糖尿病管理、抗氧化剂和增强葡萄糖转运体。本研究不包括用于治疗糖尿病以外疾病的植物。通过检索,611 种经鉴定具有抗糖尿病特性的药用植物符合条件,并根据其报告的可能作用模式进行了分组。20.6%的植物通过防止氧化应激发挥抗糖尿病作用;11.6%的植物通过刺激胰岛素分泌、抑制胰岛素降解和减少胰岛素抵抗发挥作用。此外,10.8%的植物能抑制碳水化合物的胃肠消化酶,2.8%的植物被推测能调节葡萄糖代谢酶,54.2%的植物通过非特异性或多种途径发挥作用,还有一些植物的抗糖尿病作用模式尚未确定。这项研究表明,大多数具有降血糖作用的植物的确切机制或作用方式还有待探索。因此,科学家们会发现本文对他们未来的研究很有帮助。本文还可作为一个潜在的线索,便于在药物发现过程中协调具有相关作用模式的植物,从而达到治疗糖尿病的目的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Phytomedicine approach for management of diabetes mellitus: an overview of scientifically confirmed medicinal plants with hypoglycaemic properties and their probable mechanism of action

Diabetes mellitus is a metabolic disorder that can lead to various complications affecting the heart, kidney, and eye. Several synthetic and natural products have been used for disease management, but the disease still remains a global challenge. The use of plants as an alternative management for diabetes has been on the rise. Regrettably, the comprehensive repository is not available to guide future research in the area of plants with a related mechanism of action for the development of an effective drug. To identify and compile medicinal plants frequently used with proven scientific hypoglycaemic properties and their possible modes of action. This was done through a literature search of scientific databases using search tools like DOAJ, EMBASE, Europe PMC, FSTA, Google Scholar, HubMed, Indian Citation Index, Medline Plus, Merck Index, PubMed, ScienceDirect, Science3open, Science Open, SciFinder, Scirus, Core, Scopus, Semantic Scholar, Shodhganga, and World Wide Science. Search keywords included: medicinal plants, antidiabetics, hypoglycaemic, alpha-amylases/glucosidase inhibition, glucose metabolic enzymes, antihyperglycaemia, insulin secretion/surrogate, β-cell amelioration, phytochemicals, diabetes management, anti-oxidant, and enhance glucose transporters. The study excludes plants used in the management of diseases other than diabetes mellitus. From the search, 611 authenticated medicinal plants with anti-diabetic properties were eligible and grouped according to their reported probable mode of action. Precisely 20.6% of the plants exhibited their anti-diabetic effect via prevention of oxidative stress; 11.6% acted through stimulation of insulin secretion, inhibition of insulin degradation, and reduction of insulin resistance. Also, 10.8% inhibited enzymes of carbohydrate gastrointestinal digestion, 2.8% were postulated to regulate enzymes of glucose metabolism, and 54.2% acted via nonspecific or multiple means, as well as those whose anti-diabetic mode of action was yet to be identified. This study has shown that the exact mechanisms or mode of action of the majority of plants with hypoglycaemic properties are yet to be explored. Scientists would therefore find this paper useful in their future research. This paper may also serve as a potential lead for the easy harmonization of plants with a related mode of action in the drug discovery process targeted at the management of diabetes mellitus.

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来源期刊
Phytochemistry Reviews
Phytochemistry Reviews PLANT SCIENCES-
CiteScore
16.30
自引率
2.60%
发文量
54
审稿时长
2 months
期刊介绍: Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.
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