利用纳滤从甜菜根模型提取物中提取甜菜苷:参数估计和敏感性分析

IF 2.8 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Journal of chemical technology and biotechnology Pub Date : 2024-06-20 DOI:10.1002/jctb.7698
Ashwani Kumar Tiwari, Manish Jain
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引用次数: 0

摘要

背景如今,全球对天然化合物的研究越来越重视。最近,天然生物活性化合物因其出色的物理化学特性以及在食品和制药行业的特殊用途而受到研究人员的关注。然而,如何将这些生物活性化合物从其来源地分离和浓缩出来,仍然是对其商业用途盈利的巨大挑战。目前的研究侧重于应用一种简便的纳滤法,利用聚酰胺纳滤膜从甜菜根提取物模型溶液中回收甜菜苷。此外,还使用了三参数 Spiegler-Kedem 模型来确定膜的传输参数,并从理论上预测膜的性能。结果表明,在 0.6 MPa 压力和 600 mL min-1 流量条件下,膜的最高截留率为 99%,渗透通量为 3.14 ⨯ 10-5 m3 m-2 s-1。通过 Spiegler-Kedem 模型获得的数据与实验观测结果一致。对敏感性分析的模拟显示,比水力渗透率和跨膜压力对渗透通量和截留率的影响最大。较高的跨膜压力和较高的进料流速是获得较高排斥率的理想操作条件。基于方差的敏感性分析表明,跨膜压力和水力渗透性是影响渗透通量和排斥率的最大参数。© 2024 化学工业学会(SCI)。
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Concentration of betanin from model beetroot extracts by using nanofiltration: parameter estimation and sensitivity analysis

BACKGROUND

Nowadays, research focusing on natural compounds is getting more importance across the globe. Recently, natural bioactive compounds have gained the attention of researchers as a consequence of their exemplary physicochemical properties and exceptional utility in the food and pharma industries. However, separating and concentrating these bioactive compounds from their origin sources still poses a considerable challenge to their profitable commercial usage. The current study focuses on the application of a facile nanofiltration method for recovering betanin from model beetroot extract solutions using a polyamide nanofiltration membrane. Furthermore, the three-parameter Spiegler–Kedem model was used to determine the transport parameters of the membrane and theoretically predict the performance of the membrane. Additionally, variance-based sensitivity analysis methods were deployed to study the sensitivity of different operating and membrane transport parameters.

RESULT

The results indicate that the membrane exhibited the highest rejection of 99% and permeate flux of 3.14 ⨯ 10−5 m3 m−2 s−1 at 0.6 MPa pressure and 600 mL min−1 flow rate. The data obtained through the Spiegler–Kedem model were coherent with the experimental observations. Simulations on sensitivity analysis revealed that specific hydraulic permeability and cross-membrane pressure majorly influence permeate flux and rejection.

CONCLUSION

This study showed that nanofiltration with 150 Da cut-off membranes effectively concentrated betanin with 99% rejection. Higher cross-membrane pressure and higher feed flow rates were preferable operating conditions for higher rejections. Variance-based sensitivity analysis showed that cross-membrane pressure and hydraulic permeability are the most influential parameters affecting permeate flux and rejection. © 2024 Society of Chemical Industry (SCI).

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来源期刊
CiteScore
7.00
自引率
5.90%
发文量
268
审稿时长
1.7 months
期刊介绍: Journal of Chemical Technology and Biotechnology(JCTB) is an international, inter-disciplinary peer-reviewed journal concerned with the application of scientific discoveries and advancements in chemical and biological technology that aim towards economically and environmentally sustainable industrial processes.
期刊最新文献
Issue Information Adsorption behavior of graphite‐like walnut shell biochar modified with ammonia for ciprofloxacin in aqueous solution Eco‐friendly approaches for synthesis of indolyl 1H‐pyrroles using rice‐husk‐derived carbonaceous sulfonation as the green catalyst Impact of neutrophil‐activating protein conservation on diagnostic tests and vaccine design Issue Information
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