用于骨修复的新型生物活性粘合剂的超快凝固率

IF 2.4 3区 化学 Q3 POLYMER SCIENCE Iranian Polymer Journal Pub Date : 2024-06-23 DOI:10.1007/s13726-024-01354-1
Ning Gu, Qingxiao Liu, Qichao Liu, Ying Ren, Xiaodong Liu, Youyi Sun, Yang Cao
{"title":"用于骨修复的新型生物活性粘合剂的超快凝固率","authors":"Ning Gu,&nbsp;Qingxiao Liu,&nbsp;Qichao Liu,&nbsp;Ying Ren,&nbsp;Xiaodong Liu,&nbsp;Youyi Sun,&nbsp;Yang Cao","doi":"10.1007/s13726-024-01354-1","DOIUrl":null,"url":null,"abstract":"<div><p>Polymer bone binder has attracted lots of attention due to its facile preparation, biodegradability, and so on. However, achieving strong adhesion, easy preparation, and fast setting rate for polymer bone binding is still a great challenge. So, here, a new polymer bone binder is developed and prepared to simultaneously improve setting rate and strength. The bone binder is composed of polyethyleneglycol, ethylhydroacrylate, chitosan, and SiO<sub>2</sub> nanoparticles. It exhibits good biocompatibility and large bonding strength (ca. 2.0 MPa). Furthermore, the bone binder shows an ultra-fast setting rate (ca. 100 s), which is far faster than that reported in previous works. The bone binder is further evaluated to bond chicken bone, which exhibits a high binding force of 2.0 kgf in a short setting time of only 5.0 min. The good biocompatibility and the large bonding strength of the present bone binder are attributed to the green and environmentally friendly composition (e.g., cyanoacrylate, chitosan, polyethyleneglycol and SiO<sub>2</sub> nanoparticles) and cross-linking network between chitosan and SiO<sub>2</sub> nanoparticles. The ultra-fast setting process is attributed to the rapid polymerization of cyanoacrylate and the physical interaction of SiO<sub>2</sub> nanoparticles with chitosan and polyethyleneglycol. The work provides a new method to design and prepare high-performance bone binders for use in bone fracture repair.</p><h3>Graphical abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":601,"journal":{"name":"Iranian Polymer Journal","volume":null,"pages":null},"PeriodicalIF":2.4000,"publicationDate":"2024-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ultra-fast setting rate of a new bioactive binder for bone repair\",\"authors\":\"Ning Gu,&nbsp;Qingxiao Liu,&nbsp;Qichao Liu,&nbsp;Ying Ren,&nbsp;Xiaodong Liu,&nbsp;Youyi Sun,&nbsp;Yang Cao\",\"doi\":\"10.1007/s13726-024-01354-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Polymer bone binder has attracted lots of attention due to its facile preparation, biodegradability, and so on. However, achieving strong adhesion, easy preparation, and fast setting rate for polymer bone binding is still a great challenge. So, here, a new polymer bone binder is developed and prepared to simultaneously improve setting rate and strength. The bone binder is composed of polyethyleneglycol, ethylhydroacrylate, chitosan, and SiO<sub>2</sub> nanoparticles. It exhibits good biocompatibility and large bonding strength (ca. 2.0 MPa). Furthermore, the bone binder shows an ultra-fast setting rate (ca. 100 s), which is far faster than that reported in previous works. The bone binder is further evaluated to bond chicken bone, which exhibits a high binding force of 2.0 kgf in a short setting time of only 5.0 min. The good biocompatibility and the large bonding strength of the present bone binder are attributed to the green and environmentally friendly composition (e.g., cyanoacrylate, chitosan, polyethyleneglycol and SiO<sub>2</sub> nanoparticles) and cross-linking network between chitosan and SiO<sub>2</sub> nanoparticles. The ultra-fast setting process is attributed to the rapid polymerization of cyanoacrylate and the physical interaction of SiO<sub>2</sub> nanoparticles with chitosan and polyethyleneglycol. The work provides a new method to design and prepare high-performance bone binders for use in bone fracture repair.</p><h3>Graphical abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":601,\"journal\":{\"name\":\"Iranian Polymer Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2024-06-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iranian Polymer Journal\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s13726-024-01354-1\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Polymer Journal","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s13726-024-01354-1","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0

摘要

聚合物骨粘合剂因其制备简便、可生物降解等优点而备受关注。然而,如何实现聚合物骨粘合剂的强粘合性、易制备性和快速凝固率仍然是一个巨大的挑战。因此,本文开发并制备了一种新型聚合物骨粘合剂,以同时提高固化率和强度。该骨粘合剂由聚乙二醇、氢丙烯酸乙酯、壳聚糖和纳米二氧化硅组成。它具有良好的生物相容性和较大的粘合强度(约 2.0 兆帕)。此外,这种骨粘合剂还具有超快的凝固速度(约 100 秒),远远快于之前的研究成果。我们进一步评估了骨粘合剂粘合鸡骨的效果,其粘合力高达 2.0 kgf,而固化时间仅为 5.0 分钟。本骨粘合剂具有良好的生物相容性和较大的粘合力,这归功于其绿色环保的成分(如氰基丙烯酸酯、壳聚糖、聚乙二醇和二氧化硅纳米粒子)以及壳聚糖和二氧化硅纳米粒子之间的交联网络。超快固化过程归功于氰基丙烯酸酯的快速聚合以及二氧化硅纳米粒子与壳聚糖和聚乙二醇的物理相互作用。这项研究为设计和制备用于骨折修复的高性能骨粘合剂提供了一种新方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Ultra-fast setting rate of a new bioactive binder for bone repair

Polymer bone binder has attracted lots of attention due to its facile preparation, biodegradability, and so on. However, achieving strong adhesion, easy preparation, and fast setting rate for polymer bone binding is still a great challenge. So, here, a new polymer bone binder is developed and prepared to simultaneously improve setting rate and strength. The bone binder is composed of polyethyleneglycol, ethylhydroacrylate, chitosan, and SiO2 nanoparticles. It exhibits good biocompatibility and large bonding strength (ca. 2.0 MPa). Furthermore, the bone binder shows an ultra-fast setting rate (ca. 100 s), which is far faster than that reported in previous works. The bone binder is further evaluated to bond chicken bone, which exhibits a high binding force of 2.0 kgf in a short setting time of only 5.0 min. The good biocompatibility and the large bonding strength of the present bone binder are attributed to the green and environmentally friendly composition (e.g., cyanoacrylate, chitosan, polyethyleneglycol and SiO2 nanoparticles) and cross-linking network between chitosan and SiO2 nanoparticles. The ultra-fast setting process is attributed to the rapid polymerization of cyanoacrylate and the physical interaction of SiO2 nanoparticles with chitosan and polyethyleneglycol. The work provides a new method to design and prepare high-performance bone binders for use in bone fracture repair.

Graphical abstract

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Iranian Polymer Journal
Iranian Polymer Journal 化学-高分子科学
CiteScore
4.90
自引率
9.70%
发文量
107
审稿时长
2.8 months
期刊介绍: Iranian Polymer Journal, a monthly peer-reviewed international journal, provides a continuous forum for the dissemination of the original research and latest advances made in science and technology of polymers, covering diverse areas of polymer synthesis, characterization, polymer physics, rubber, plastics and composites, processing and engineering, biopolymers, drug delivery systems and natural polymers to meet specific applications. Also contributions from nano-related fields are regarded especially important for its versatility in modern scientific development.
期刊最新文献
Pronouncedly elevated impact toughness of isotactic polypropylene upon annealing realized by introducing alkyl-terminated hyperbranched polyester Rice husk/glass fiber-reinforced poly(lactic acid) hybrid composites: rheological and dynamic mechanical study Optimizing drilling parameters for unidirectional glass fiber/nanoclay-epoxy matrix composites using gray relational analysis and response surface methodology Physio-mechanical and thermal characteristics of Mimosa pudica microfibers impregnated novel PLA biocomposite Biodegradable, biocompatible, and self-healing, injectable hydrogel based on oxidized Azadirachta indica gum and carboxymethyl chitosan through dynamic imine-linkage for biomedical application
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1