Mukul Barwant, Vanita Karande, Parita Basnet, Deepak Kumar, Saman Sargazi, Mahmoud Mirzaei, Majid S. Jabir, Dnyaneshwar Sanap, Suresh Ghotekar
{"title":"对利用马尾藻生物合成的新型氧化镍/氧化镍纳米粒子的抗氧化和抗癌特性的深入研究","authors":"Mukul Barwant, Vanita Karande, Parita Basnet, Deepak Kumar, Saman Sargazi, Mahmoud Mirzaei, Majid S. Jabir, Dnyaneshwar Sanap, Suresh Ghotekar","doi":"10.1007/s10971-024-06446-1","DOIUrl":null,"url":null,"abstract":"<p>Presently, the utilization of nanomaterials has evolved as an appealing alternative for ever-changing healthcare obstacles due to their distinctive features and multifunctional applications. This work aimed to fabricate and analyze novel NiO/Ni<sub>2</sub>O<sub>3</sub> nanoparticles (NPs) using <i>Sargassum tentorium</i> extracts and investigate their antioxidant and anticancer potentials. Diverse analytical instrumental tools were applied to explore NiO/Ni<sub>2</sub>O<sub>3</sub> NPs, including UV–vis diffuse reflectance spectroscopy (UVDRS), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), high-resolution scanning electron microscopy (HRTEM), and energy-dispersive X-ray (EDX) analyses. HRTEM images revealed mostly quasi-spherical and wire-shaped NPs with average 97 and 87 nm sizes for NiO/Ni<sub>2</sub>O<sub>3</sub> NPs. Afterward, the biological properties of the biologically manufactured NiO/Ni<sub>2</sub>O<sub>3</sub> NPs were explored. This work assessed the anticancer potential of as-fabricated NiO/Ni<sub>2</sub>O<sub>3</sub> NPs utilizing the MTT assay. The experiment assessed cell viability at doses ranging from 7.81 to 500 µg/mL during a 24 h period for the breast cancer cell line (MCF-7). The study outcomes demonstrate a concentration-dependent effect of fabricated NiO/Ni<sub>2</sub>O<sub>3</sub> NPs on MCF-7 cells. The inhibition of MCF-7 cells increases with the concentration of NiO/Ni<sub>2</sub>O<sub>3</sub> NPs, achieving an IC<sub>50</sub> value of 883.4 µg/mL in 24 h. Furthermore, the antioxidant potency of NiO/Ni<sub>2</sub>O<sub>3</sub> NPs was examined via a free radical scavenging ABTS and DPPH assay. At a concentration of 50 μg/mL, NiO/Ni<sub>2</sub>O<sub>3</sub> NPs also exhibited 74.71% ABTS scavenging and 71.62% DPPH scavenging inhibition, respectively. In conclusion, NiO/Ni<sub>2</sub>O<sub>3</sub> NPs manufactured via <i>Sargassum tenerrimum</i> extracts could be promising candidates for further biomedical applications.</p><h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3>","PeriodicalId":664,"journal":{"name":"Journal of Sol-Gel Science and Technology","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Insights into the antioxidant and anticancer properties of novel biologically synthesized NiO/Ni2O3 nanoparticles using Sargassum tenerrimum\",\"authors\":\"Mukul Barwant, Vanita Karande, Parita Basnet, Deepak Kumar, Saman Sargazi, Mahmoud Mirzaei, Majid S. Jabir, Dnyaneshwar Sanap, Suresh Ghotekar\",\"doi\":\"10.1007/s10971-024-06446-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Presently, the utilization of nanomaterials has evolved as an appealing alternative for ever-changing healthcare obstacles due to their distinctive features and multifunctional applications. This work aimed to fabricate and analyze novel NiO/Ni<sub>2</sub>O<sub>3</sub> nanoparticles (NPs) using <i>Sargassum tentorium</i> extracts and investigate their antioxidant and anticancer potentials. Diverse analytical instrumental tools were applied to explore NiO/Ni<sub>2</sub>O<sub>3</sub> NPs, including UV–vis diffuse reflectance spectroscopy (UVDRS), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), high-resolution scanning electron microscopy (HRTEM), and energy-dispersive X-ray (EDX) analyses. HRTEM images revealed mostly quasi-spherical and wire-shaped NPs with average 97 and 87 nm sizes for NiO/Ni<sub>2</sub>O<sub>3</sub> NPs. Afterward, the biological properties of the biologically manufactured NiO/Ni<sub>2</sub>O<sub>3</sub> NPs were explored. This work assessed the anticancer potential of as-fabricated NiO/Ni<sub>2</sub>O<sub>3</sub> NPs utilizing the MTT assay. The experiment assessed cell viability at doses ranging from 7.81 to 500 µg/mL during a 24 h period for the breast cancer cell line (MCF-7). The study outcomes demonstrate a concentration-dependent effect of fabricated NiO/Ni<sub>2</sub>O<sub>3</sub> NPs on MCF-7 cells. The inhibition of MCF-7 cells increases with the concentration of NiO/Ni<sub>2</sub>O<sub>3</sub> NPs, achieving an IC<sub>50</sub> value of 883.4 µg/mL in 24 h. Furthermore, the antioxidant potency of NiO/Ni<sub>2</sub>O<sub>3</sub> NPs was examined via a free radical scavenging ABTS and DPPH assay. At a concentration of 50 μg/mL, NiO/Ni<sub>2</sub>O<sub>3</sub> NPs also exhibited 74.71% ABTS scavenging and 71.62% DPPH scavenging inhibition, respectively. 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Insights into the antioxidant and anticancer properties of novel biologically synthesized NiO/Ni2O3 nanoparticles using Sargassum tenerrimum
Presently, the utilization of nanomaterials has evolved as an appealing alternative for ever-changing healthcare obstacles due to their distinctive features and multifunctional applications. This work aimed to fabricate and analyze novel NiO/Ni2O3 nanoparticles (NPs) using Sargassum tentorium extracts and investigate their antioxidant and anticancer potentials. Diverse analytical instrumental tools were applied to explore NiO/Ni2O3 NPs, including UV–vis diffuse reflectance spectroscopy (UVDRS), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), high-resolution scanning electron microscopy (HRTEM), and energy-dispersive X-ray (EDX) analyses. HRTEM images revealed mostly quasi-spherical and wire-shaped NPs with average 97 and 87 nm sizes for NiO/Ni2O3 NPs. Afterward, the biological properties of the biologically manufactured NiO/Ni2O3 NPs were explored. This work assessed the anticancer potential of as-fabricated NiO/Ni2O3 NPs utilizing the MTT assay. The experiment assessed cell viability at doses ranging from 7.81 to 500 µg/mL during a 24 h period for the breast cancer cell line (MCF-7). The study outcomes demonstrate a concentration-dependent effect of fabricated NiO/Ni2O3 NPs on MCF-7 cells. The inhibition of MCF-7 cells increases with the concentration of NiO/Ni2O3 NPs, achieving an IC50 value of 883.4 µg/mL in 24 h. Furthermore, the antioxidant potency of NiO/Ni2O3 NPs was examined via a free radical scavenging ABTS and DPPH assay. At a concentration of 50 μg/mL, NiO/Ni2O3 NPs also exhibited 74.71% ABTS scavenging and 71.62% DPPH scavenging inhibition, respectively. In conclusion, NiO/Ni2O3 NPs manufactured via Sargassum tenerrimum extracts could be promising candidates for further biomedical applications.
期刊介绍:
The primary objective of the Journal of Sol-Gel Science and Technology (JSST), the official journal of the International Sol-Gel Society, is to provide an international forum for the dissemination of scientific, technological, and general knowledge about materials processed by chemical nanotechnologies known as the "sol-gel" process. The materials of interest include gels, gel-derived glasses, ceramics in form of nano- and micro-powders, bulk, fibres, thin films and coatings as well as more recent materials such as hybrid organic-inorganic materials and composites. Such materials exhibit a wide range of optical, electronic, magnetic, chemical, environmental, and biomedical properties and functionalities. Methods for producing sol-gel-derived materials and the industrial uses of these materials are also of great interest.