{"title":"通过吸附纳米铈及其氧化能力高效灭活流感病毒","authors":"Shota Sekiguchi, Eisuke Umezawa, Hiroko Ito Yamanaka, Kan Fujino, Takahiro Motoshiromizu, Miho Kawanishi Ouchi, Shunsuke Murai, Tomohide Masuda, Masateru Ito, Hitoshi Nobumasa, Satoshi Taharaguchi","doi":"10.1093/chemle/upae124","DOIUrl":null,"url":null,"abstract":"This study investigated the stabilizer's impact on nanoceria's antiviral activity. The positively charged nanoceria dispersion showed potent activity against the influenza virus, reducing the viral titer by over 4.0 log10 pfu/mL within 1 h, surpassing EN14476 criteria. It also inactivated the virus within 15 s, decreasing the infection titer by 2.2 log10 pfu/mL, and maintained efficacy even under bovine serum albumin loading.","PeriodicalId":9862,"journal":{"name":"Chemistry Letters","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Efficient Inactivation of Influenza Virus Through Adsorption of Nanoceria and its Oxidative Power\",\"authors\":\"Shota Sekiguchi, Eisuke Umezawa, Hiroko Ito Yamanaka, Kan Fujino, Takahiro Motoshiromizu, Miho Kawanishi Ouchi, Shunsuke Murai, Tomohide Masuda, Masateru Ito, Hitoshi Nobumasa, Satoshi Taharaguchi\",\"doi\":\"10.1093/chemle/upae124\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This study investigated the stabilizer's impact on nanoceria's antiviral activity. The positively charged nanoceria dispersion showed potent activity against the influenza virus, reducing the viral titer by over 4.0 log10 pfu/mL within 1 h, surpassing EN14476 criteria. It also inactivated the virus within 15 s, decreasing the infection titer by 2.2 log10 pfu/mL, and maintained efficacy even under bovine serum albumin loading.\",\"PeriodicalId\":9862,\"journal\":{\"name\":\"Chemistry Letters\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-06-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemistry Letters\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1093/chemle/upae124\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry Letters","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1093/chemle/upae124","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Efficient Inactivation of Influenza Virus Through Adsorption of Nanoceria and its Oxidative Power
This study investigated the stabilizer's impact on nanoceria's antiviral activity. The positively charged nanoceria dispersion showed potent activity against the influenza virus, reducing the viral titer by over 4.0 log10 pfu/mL within 1 h, surpassing EN14476 criteria. It also inactivated the virus within 15 s, decreasing the infection titer by 2.2 log10 pfu/mL, and maintained efficacy even under bovine serum albumin loading.
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