空气污染对生活在不同环境地区人群的部分免疫系统参数、8-异前列腺素和α-1-抗胰蛋白酶的影响

IF 6 3区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Environmental Sciences Europe Pub Date : 2024-07-02 DOI:10.1186/s12302-024-00948-z
Vítězslav Jiřík, Ondřej Machaczka, Petra Riedlová, Dagmar Kramná, Grzegorz Siemiatkowski, Leszek Ośródka, Ewa Krajny, Antonín Ambrož, Jan Topinka, Pavel Rössner
{"title":"空气污染对生活在不同环境地区人群的部分免疫系统参数、8-异前列腺素和α-1-抗胰蛋白酶的影响","authors":"Vítězslav Jiřík, Ondřej Machaczka, Petra Riedlová, Dagmar Kramná, Grzegorz Siemiatkowski, Leszek Ośródka, Ewa Krajny, Antonín Ambrož, Jan Topinka, Pavel Rössner","doi":"10.1186/s12302-024-00948-z","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Air pollution is associated with adverse health effects, especially on the respiratory and cardiovascular systems, but according to recent research, even in cognitive health, metabolic, and immune systems. The objective was to analyse the effect of long-term exposure to air pollution on selected immune system parameters, 8-isoprostane a parameter of oxidative stress, and alpha-1-antitrypsin a protease inhibitor.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>The number of 381 probands aged 35–65 from two differently polluted regions was included. Lifetime exposures to PM<sub>10</sub>, PM<sub>2.5</sub>, NO<sub>2</sub>, B(a)P, and benzene for each proband were calculated based on historical pollutant concentrations observed. The selected blood parameters were analysed in relation to independent variables (air pollutants, socioeconomic factors, etc.) using multiple regression. Possible covariates were determined. In its end, the study was conceived as a case–control study, and the odds ratio was quantified, expressing the strength of the association of the monitored parameters with the region.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The average lifetime exposures to air pollution were significantly different between the two regions. Significant effects of the region were observed on IgM, IL-6, 8-isoprostane, and alpha-1-antitrypsin levels. The strongest positive association was observed between 8-isoprostane levels and benzene, PM<sub>2.5</sub>, PM<sub>10</sub> and B(a)P. Odds ratio was 3.21 (95%CI 1.61–6.38). A significant negative association between all pollutants and IgM levels was observed even with covariate adjustment. Odds ratio was 1.80 (95%CI 1.15–2.82). A significant negative association between the alpha-1-antitrypsin levels and PM<sub>10</sub>, PM<sub>2.5</sub>, and benzene was found, independent of smoking as a covariate factor. Odds ratio was 1.77 (95%CI 1.09–2.87). In the case of IL-6, a significant effect of especially sleep as a covariate was observed. After covariates adjustment, a significant positive association between the IL-6 levels and PM<sub>10</sub> and benzene was only observed. The odds ratio was 1.95 (95%CI 1.28–2.97).</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>The study confirmed that long-term exposure to air pollutants is associated with reduced levels of the protease inhibitor alpha-1-antitrypsin and decreased immune system performance by IgM. Furthermore, long-term exposure to air pollutants was associated with increased oxidative stress in humans, measured by 8-isoprostane levels. Residents who live in an industrial, environmentally polluted region showed elevated levels of IL-6.</p>","PeriodicalId":546,"journal":{"name":"Environmental Sciences Europe","volume":null,"pages":null},"PeriodicalIF":6.0000,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effect of air pollution on selected immune system parameters, 8-isoprostane, and alpha-1-antitrypsin of people living in environmentally distinct regions\",\"authors\":\"Vítězslav Jiřík, Ondřej Machaczka, Petra Riedlová, Dagmar Kramná, Grzegorz Siemiatkowski, Leszek Ośródka, Ewa Krajny, Antonín Ambrož, Jan Topinka, Pavel Rössner\",\"doi\":\"10.1186/s12302-024-00948-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Background</h3><p>Air pollution is associated with adverse health effects, especially on the respiratory and cardiovascular systems, but according to recent research, even in cognitive health, metabolic, and immune systems. The objective was to analyse the effect of long-term exposure to air pollution on selected immune system parameters, 8-isoprostane a parameter of oxidative stress, and alpha-1-antitrypsin a protease inhibitor.</p><h3 data-test=\\\"abstract-sub-heading\\\">Methods</h3><p>The number of 381 probands aged 35–65 from two differently polluted regions was included. Lifetime exposures to PM<sub>10</sub>, PM<sub>2.5</sub>, NO<sub>2</sub>, B(a)P, and benzene for each proband were calculated based on historical pollutant concentrations observed. The selected blood parameters were analysed in relation to independent variables (air pollutants, socioeconomic factors, etc.) using multiple regression. Possible covariates were determined. In its end, the study was conceived as a case–control study, and the odds ratio was quantified, expressing the strength of the association of the monitored parameters with the region.</p><h3 data-test=\\\"abstract-sub-heading\\\">Results</h3><p>The average lifetime exposures to air pollution were significantly different between the two regions. Significant effects of the region were observed on IgM, IL-6, 8-isoprostane, and alpha-1-antitrypsin levels. The strongest positive association was observed between 8-isoprostane levels and benzene, PM<sub>2.5</sub>, PM<sub>10</sub> and B(a)P. Odds ratio was 3.21 (95%CI 1.61–6.38). A significant negative association between all pollutants and IgM levels was observed even with covariate adjustment. Odds ratio was 1.80 (95%CI 1.15–2.82). A significant negative association between the alpha-1-antitrypsin levels and PM<sub>10</sub>, PM<sub>2.5</sub>, and benzene was found, independent of smoking as a covariate factor. Odds ratio was 1.77 (95%CI 1.09–2.87). In the case of IL-6, a significant effect of especially sleep as a covariate was observed. After covariates adjustment, a significant positive association between the IL-6 levels and PM<sub>10</sub> and benzene was only observed. The odds ratio was 1.95 (95%CI 1.28–2.97).</p><h3 data-test=\\\"abstract-sub-heading\\\">Conclusions</h3><p>The study confirmed that long-term exposure to air pollutants is associated with reduced levels of the protease inhibitor alpha-1-antitrypsin and decreased immune system performance by IgM. Furthermore, long-term exposure to air pollutants was associated with increased oxidative stress in humans, measured by 8-isoprostane levels. Residents who live in an industrial, environmentally polluted region showed elevated levels of IL-6.</p>\",\"PeriodicalId\":546,\"journal\":{\"name\":\"Environmental Sciences Europe\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.0000,\"publicationDate\":\"2024-07-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Environmental Sciences Europe\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://doi.org/10.1186/s12302-024-00948-z\",\"RegionNum\":3,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental Sciences Europe","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1186/s12302-024-00948-z","RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 0

摘要

背景空气污染与不良健康影响有关,尤其是对呼吸系统和心血管系统的影响,但根据最近的研究,甚至对认知健康、新陈代谢和免疫系统也有影响。本研究的目的是分析长期暴露于空气污染对某些免疫系统参数、氧化应激参数 8-异前列腺烷以及蛋白酶抑制剂 alpha-1-antitrypsin 的影响。根据观察到的历史污染物浓度,计算出每个受试者一生中接触 PM10、PM2.5、二氧化氮、B(a)P 和苯的情况。使用多元回归法分析了所选血液参数与自变量(空气污染物、社会经济因素等)的关系。确定了可能的协变量。最后,研究被视为病例对照研究,并对几率进行了量化,以表示监测参数与地区的关联强度。地区对 IgM、IL-6、8-异前列腺烷和α-1-抗胰蛋白酶水平有显著影响。8-异前列腺烷水平与苯、PM2.5、PM10 和 B(a)P 之间的正相关性最强。即使进行了协变量调整,也可以观察到所有污染物与 IgM 水平之间存在明显的负相关。比值比为 1.80(95%CI 1.15-2.82)。研究发现,α-1-抗胰蛋白酶水平与 PM10、PM2.5 和苯之间存在明显的负相关,与作为协变量因素的吸烟无关。比值比为 1.77(95%CI 1.09-2.87)。就 IL-6 而言,特别是将睡眠作为协变量会产生显著影响。经过协变量调整后,仅观察到 IL-6 水平与 PM10 和苯之间存在显著的正相关。研究证实,长期暴露于空气污染物与蛋白酶抑制剂α-1-抗胰蛋白酶水平降低和免疫系统 IgM 性能下降有关。此外,根据 8-异前列腺素水平的测量,长期暴露于空气污染物与人体氧化应激增加有关。生活在工业和环境污染地区的居民体内 IL-6 水平升高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
The effect of air pollution on selected immune system parameters, 8-isoprostane, and alpha-1-antitrypsin of people living in environmentally distinct regions

Background

Air pollution is associated with adverse health effects, especially on the respiratory and cardiovascular systems, but according to recent research, even in cognitive health, metabolic, and immune systems. The objective was to analyse the effect of long-term exposure to air pollution on selected immune system parameters, 8-isoprostane a parameter of oxidative stress, and alpha-1-antitrypsin a protease inhibitor.

Methods

The number of 381 probands aged 35–65 from two differently polluted regions was included. Lifetime exposures to PM10, PM2.5, NO2, B(a)P, and benzene for each proband were calculated based on historical pollutant concentrations observed. The selected blood parameters were analysed in relation to independent variables (air pollutants, socioeconomic factors, etc.) using multiple regression. Possible covariates were determined. In its end, the study was conceived as a case–control study, and the odds ratio was quantified, expressing the strength of the association of the monitored parameters with the region.

Results

The average lifetime exposures to air pollution were significantly different between the two regions. Significant effects of the region were observed on IgM, IL-6, 8-isoprostane, and alpha-1-antitrypsin levels. The strongest positive association was observed between 8-isoprostane levels and benzene, PM2.5, PM10 and B(a)P. Odds ratio was 3.21 (95%CI 1.61–6.38). A significant negative association between all pollutants and IgM levels was observed even with covariate adjustment. Odds ratio was 1.80 (95%CI 1.15–2.82). A significant negative association between the alpha-1-antitrypsin levels and PM10, PM2.5, and benzene was found, independent of smoking as a covariate factor. Odds ratio was 1.77 (95%CI 1.09–2.87). In the case of IL-6, a significant effect of especially sleep as a covariate was observed. After covariates adjustment, a significant positive association between the IL-6 levels and PM10 and benzene was only observed. The odds ratio was 1.95 (95%CI 1.28–2.97).

Conclusions

The study confirmed that long-term exposure to air pollutants is associated with reduced levels of the protease inhibitor alpha-1-antitrypsin and decreased immune system performance by IgM. Furthermore, long-term exposure to air pollutants was associated with increased oxidative stress in humans, measured by 8-isoprostane levels. Residents who live in an industrial, environmentally polluted region showed elevated levels of IL-6.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Environmental Sciences Europe
Environmental Sciences Europe Environmental Science-Pollution
CiteScore
11.20
自引率
1.70%
发文量
110
审稿时长
13 weeks
期刊介绍: ESEU is an international journal, focusing primarily on Europe, with a broad scope covering all aspects of environmental sciences, including the main topic regulation. ESEU will discuss the entanglement between environmental sciences and regulation because, in recent years, there have been misunderstandings and even disagreement between stakeholders in these two areas. ESEU will help to improve the comprehension of issues between environmental sciences and regulation. ESEU will be an outlet from the German-speaking (DACH) countries to Europe and an inlet from Europe to the DACH countries regarding environmental sciences and regulation. Moreover, ESEU will facilitate the exchange of ideas and interaction between Europe and the DACH countries regarding environmental regulatory issues. Although Europe is at the center of ESEU, the journal will not exclude the rest of the world, because regulatory issues pertaining to environmental sciences can be fully seen only from a global perspective.
期刊最新文献
Unlocking the potential of data harmonization and FAIRness in chemical risk assessment: lessons from practice and insights for policy development Heavy metal contamination and potential health risks in upland rice-producing soils of rotational shifting cultivation in northern Thailand Microbial biopesticides are inhibited by honey bee royal jelly and in vitro larval diet COVID-19 pandemic microplastics environmental impacts predicted by deep random forest (DRF) predictive model Is environmental risk assessment possible with the alternatives to acute fish toxicity test? Case study with pharmaceuticals
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1