An efficient strategy for alkoxy halogenation addition of olefins catalyzed by polyoxometalate-based iron catalyst

The halogenation of alkenes is a crucial pathway in forming C-X bonds, with a significant impact on organic synthesis and pharmaceuticals. However, traditional methodologies present potential hazards to both the environment and human health, making the quest for green and efficient halogenation methods paramount. In this study, we introduce a novel iron catalyst based on a polyoxometalate, (NH₄)₃[FeMo₆O₁₈(OH)₆], simplified as Fe(III)Mo₆. Employing this catalyst, a plethora of styrene derivatives and alcohols were efficiently and successfully converted to the corresponding halogenated products. Also, our catalyst showed excellent performance toward the reaction with various substrates. Moreover, it demonstrates high stability and activity in the cycle test. In addition, we also described the reaction mechanism based on the control experiment. The catalyst exhibits non-toxic, green, and environmentally friendly characteristics that provide future industrialization potential.