评估口服纳米姜黄素对支气管非变应性哮喘患者呼吸功能和生活质量的疗效:随机对照试验。

IF 1.9 Q3 CHEMISTRY, MEDICINAL Avicenna Journal of Phytomedicine Pub Date : 2024-03-01 DOI:10.22038/AJP.2023.22826
Shahrzad Mohammadzadeh Lari, Amir Hooshang Mohamadpour, Davood Attaran, Mahmodreza Jafari, Omid Arasteh, Maryam Emadzadeh, Mahnaz Mozdourian, Soroush Attaran, Zahra Javidarabshahi
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引用次数: 0

摘要

目的:哮喘是一种常见疾病,姜黄素对炎症性疾病有一定疗效。本研究探讨了纳米姜黄素对哮喘的疗效:在这项双盲随机临床试验中,60 名非变应性支气管哮喘患者被随机分为两组,即干预组(30 人)和对照组(30 人)。干预组除了接受常规治疗外,还服用 40 毫克纳米姜黄素(软凝胶),每天三次,对照组服用安慰剂。在为期 60 天的研究中,患者使用肺活量计测量第一秒用力呼气容积(FEV1)。哮喘控制测试(ACT)每 30 天完成一次,哮喘生活质量问卷(AQLQ)在研究开始和结束时完成:共有 31 名患者(51.7%)为男性,平均年龄为(51.45±12.58)岁。FEV1有所改善,但干预组和对照组之间无明显差异。ACT 和 AQLQ 领域得分明显改善。结论:结论:给药剂量的纳米姜黄素对哮喘患者的标准治疗没有增效作用。
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Evaluation of oral nano-curcumin efficacy on respiratory function and quality of life in patients with bronchial non-atopic asthma: A randomized controlled trial.

Objective: Asthma is a common disease and curcumin has modest effect in inflammatory disorders. This study investigated the efficacy of nano-curcumin on asthma.

Materials and methods: In this double-blinded randomized clinical trial, 60 patients with non-atopic bronchial asthma were randomly stratified in two groups of intervention (N=30) and control (N=30) groups. Apart from their standard treatment, the intervention group received 40 mg nano-curcumin (soft gel) three times daily while the control group received placebo. During the 60-day study, patients were assessed using spirometry to measure Forced expiratory volume in first second (FEV1). Asthma control test (ACT) was completed every 30 days and asthma quality of life questionnaire (AQLQ) was completed at the first and end of the study.

Results: Totally, 31 patients (51.7%) were male and the mean age was 51.45±12.58 years. FEV1 was improved but there was no significant difference between intervention and control groups. ACT and AQLQ domains scores significantly improved. However, it was not statistically different between control and intervention groups.

Conclusion: Nano-curcumin at administered dosage had no additive effect on the standard treatment in asthmatic patients.

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来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
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