Phytopaj ) Ferula assa-foetida L. oleo gum resin and tragacanth( 对 COVID-19 患者的影响:随机临床试验。

IF 1.9 Q3 CHEMISTRY, MEDICINAL Avicenna Journal of Phytomedicine Pub Date : 2024-03-01 DOI:10.22038/AJP.2023.22800
Hamid Reza Bahrami-Taghanaki, Hamidreza Hoseinzadeh, Shokouhsadat Hamedi, Majid Jafari Nejad-Bajestani, Nayereh Esmaeilzadeh, Hasan Abdollahzadeh, Seyedehmasoume Hoseini-Asil, Gholamreza Haghighi, Amin Bojdi
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引用次数: 0

摘要

目的:外源性硫化氢(H2S)对呼吸系统疾病有积极作用。阿魏的油胶中含有这种化合物。本研究评估了阿魏油胶树脂和黄精(Phytopaj)对 COVID-19 患者的影响:在马什哈德对住院的 COVID-19 患者进行了随机、单盲、对照试验(RCT)第二阶段研究。在这项随机对照试验中,122 名患者被随机分配接受为期 14 天的口服 Phytopaj 加普通治疗或仅接受普通治疗。外周血淋巴细胞计数(LC)和血氧饱和度(PO2)的变化是终点:结果:干预前,Phytopaj对比普通治疗的PO2平均±SD分别为91.86±4.62和91.41±9.18,干预后分别为93.22±4.26和91.91±5.92 mmHg;干预前,外周血淋巴细胞计数平均±SD分别为1015.90±500.55和1104.28±543.61,干预后分别为1652.27±921.38和1326.12±719.28/μL:结论:Phyopaj 对中度 Covid19 患者最有用,在获得更多认识之前,不建议老年患者和合并症患者使用。
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The effect of Phytopaj ) Ferula assa-foetida L. oleo gum resin and tragacanth( in patients with COVID-19: A randomized clinical trial.

Objective: Exogenous hydrogen sulfide (H2S) has a positive effect on respiratory diseases. Oleo-gum of Ferula assa-foetida contains this compound. This study assessed the effects of Ferula assa-foetida L. oleo gum resin and tragacanth (Phytopaj) on patients with COVID-19.

Materials and methods: A randomized, single-blinded, controlled trial (RCT) phase 2 was conducted in Mashhad on hospitalized COVID-19 patients. In this RCT, 122 patients were randomly assigned to either receive a 14-day oral phytopaj plus ordinary treatment or ordinary treatment only. Changes in peripheral blood lymphocyte count (LC) and blood oxygen saturation (PO2) were the endpoints.

Results: Mean±SD of PO2 in Phytopaj comparison ordinary treatment before intervention was 91.86±4.62 and 91.41±9.18, after the intervention it was 93.22±4.26 and 91.91±5.92 mmHg; before intervention, mean±SD of peripheral blood lymphocyte count was 1015.90±500.55, and 1104.28±543.61, and after intervention, it was 1652.27±921.38 and 1326.12±719.28/μL respectively.

Conclusion: Phyopaj is most useful in moderate stages of Covid19, and it is not recommended for elderly patients and patients with comorbidity until more insight is gained.

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来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
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