来自 Lysimachia laxa Baudo 的齐墩果烷型皂甙及其抗菌活性。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-09-20 DOI:10.1093/bbb/zbae095

Nguyen Thi Luyen, Nguyen Tien Dat, Do Hoang Giang, Nguyen Thi Kim Thuy, Bui Huu Tai, Phan Thi Thanh Huong, Le Thi Phuong Quynh, Duong Thi Thuy, SeonJu Park, Nguyen Xuan Nhiem

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引用次数: 0

摘要

从 Lysimachia laxa Baudo 的气生部分分离出了七种新的齐墩果烷型三萜皂甙，即 Lysimaponins A-G。通过光谱和化学方法的分析，阐明了它们的化学结构。评估了所有化合物对铜绿微囊藻、副溶血性弧菌、哈维氏弧菌、弧菌、霍乱弧菌和藻溶弧菌的抗菌效果。所有化合物对蓝藻铜绿微囊藻都有很强的抗菌活性，其 IC50 值从 14.4 ± 1.2 到 35.3 ± 2.2 µg/mL 不等。化合物 1、2、4-7 可抑制副溶血弧菌，其 MIC 值介于 64 至 256 µg/mL 之间。结果表明，腊肠皂苷可能是潜在的抗蓝藻菌药物。

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Oleanane-type saponins from Lysimachia laxa Baudo and their antibacterial activities.

Seven new oleanane-type triterpene saponins, lysimaponins A-G, were isolated from aerial parts of Lysimachia laxa Baudo. Their chemical structures have been elucidated by analysis of spectroscopic and chemical methods. All compounds were evaluated for their antibacterial effects against Microcystis aeruginosa, Vibrio parahaemolyticus, V. harveyi, V. vulinificus, V. cholerae, and V. alginolyticus. All compounds showed potent antibacterial activities against the cyanobacteria M. aeruginosa with IC50 values ranging from 14.4 ± 1.2 to 35.3 ± 2.2 µg/mL. Compounds 1, 2, 4-7 inhibited V. parahaemolyticus with MIC values ranging from 64 to 256 µg/mL. The results suggested that saponins from L. laxa could be potential anti-cyanobacteria agents.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.