肠道衍生短链脂肪酸与巨噬细胞调节:探索肺部真菌感染的治疗潜力。

IF 8.4 2区 医学 Q1 ALLERGY Clinical Reviews in Allergy & Immunology Pub Date : 2024-06-01 Epub Date: 2024-07-05 DOI:10.1007/s12016-024-08999-z
Qian Xie, Qinhui Li, Hong Fang, Rong Zhang, Huan Tang, Lin Chen
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引用次数: 0

摘要

短链脂肪酸(SCFA),如醋酸酯、丙酸酯和丁酸酯,可调节免疫细胞的功能,尤其是巨噬细胞的功能。本综述探讨了 SCFAs 在肺部真菌感染中的潜在治疗应用,由于肺部真菌感染的高死亡率和抗真菌耐药性,肺部真菌感染已成为人们关注的焦点。SCFAs 可通过促进吞噬体与溶酶体融合、增加活性氧生成和平衡细胞因子反应来增强巨噬细胞功能。由曲霉菌等病原体引起的肺部真菌感染在免疫力低下的患者中非常普遍,包括糖尿病患者、慢性阻塞性肺病患者和使用大剂量皮质类固醇的患者。在这些情况下,SCFAs 有望改善巨噬细胞的功能。然而,SCFAs 的应用必须与潜在的副作用相平衡,包括肠道微生物群破坏和代谢紊乱。要优化 SCFA 治疗以控制肺部真菌感染,还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Gut-Derived Short-Chain Fatty Acids and Macrophage Modulation: Exploring Therapeutic Potentials in Pulmonary Fungal Infections.

Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, modulate immune cell functions, particularly macrophages. This review explores the potential therapeutic applications of SCFAs in pulmonary fungal infections, a critical concern due to their high mortality rates and antifungal resistance. SCFAs enhance macrophage functions by promoting phagosome-lysosome fusion, increasing reactive oxygen species production, and balancing cytokine responses. Pulmonary fungal infections, caused by pathogens like Aspergillus fumigatus, are prevalent in immunocompromised patients, including those with diabetes, chronic obstructive pulmonary disease, and those on high-dose corticosteroids. SCFAs have shown promise in improving macrophage function in these contexts. However, the application of SCFAs must be balanced against potential side effects, including gut microbiota disruption and metabolic disorders. Further research is needed to optimize SCFA therapy for managing pulmonary fungal infections.

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来源期刊
CiteScore
22.30
自引率
1.10%
发文量
58
审稿时长
6-12 weeks
期刊介绍: Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.
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