Nogapendekin alfa Inbakicept：首次批准。

IF 13 1区医学 Q1 PHARMACOLOGY & PHARMACY Drugs Pub Date : 2024-07-01 Epub Date: 2024-07-05 DOI:10.1007/s40265-024-02060-1

Susan J Keam

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引用次数: 0

摘要

Nogapendekin alfa inbakicept（ANKTIVA®；nogapendekin alfa inbakicept-pmln）是一种重组白细胞介素-15（IL-15）超拮抗剂蛋白复合物，由 ImmunityBio, Inc.的间接全资子公司 Altor BioScience, LLC 开发，用于治疗实体癌、血癌和艾滋病病毒感染。2024 年 4 月，nogapendekin alfa inbakicept 在美国获准与卡介苗（BCG）一起用于治疗对卡介苗无反应的非肌浸润性膀胱癌（NMIBC）伴有或不伴有乳头状肿瘤的原位癌（CIS）的成年患者。本文总结了诺加培酮α inbakicept 开发过程中的里程碑事件，这些事件促成了诺加培酮α inbakicept 首次获批用于癌症治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nogapendekin alfa Inbakicept: First Approval.

Nogapendekin alfa inbakicept (ANKTIVA^®; nogapendekin alfa inbakicept-pmln) is a recombinant interleukin-15 (IL-15) superagonist protein complex being developed by Altor BioScience, LLC, an indirect wholly owned subsidiary of ImmunityBio, Inc., for the treatment of solid and haematological cancers and HIV infection. In April 2024, nogapendekin alfa inbakicept was approved for use with Bacillus Calmette-Guérin (BCG) for the treatment of adult patients with BCG-unresponsive non-muscle invasive bladder cancer (NMIBC) with carcinoma in situ (CIS) with or without papillary tumours in the USA. This article summarizes the milestones in the development of nogapendekin alfa inbakicept leading to this first approval for the treatment of cancer.

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来源期刊

Drugs 医学-毒理学

CiteScore

22.70

自引率

0.90%

发文量

134

审稿时长

3-8 weeks

期刊介绍： Drugs is a journal that aims to enhance pharmacotherapy by publishing review and original research articles on key aspects of clinical pharmacology and therapeutics. The journal includes: Leading/current opinion articles providing an overview of contentious or emerging issues. Definitive reviews of drugs and drug classes, and their place in disease management. Therapy in Practice articles including recommendations for specific clinical situations. High-quality, well designed, original clinical research. Adis Drug Evaluations reviewing the properties and place in therapy of both newer and established drugs. AdisInsight Reports summarising development at first global approval. Moreover, the journal offers additional digital features such as animated abstracts, video abstracts, instructional videos, and podcasts to increase visibility and educational value. Plain language summaries accompany articles to assist readers with some knowledge of the field in understanding important medical advances.

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