Lucia Mencarelli, Mario Torso, Ilaria Borghi, Martina Assogna, Valentina Pezzopane, Sonia Bonnì, Francesco Di Lorenzo, Emiliano Santarnecchi, Federico Giove, Alessandro Martorana, Marco Bozzali, Gerard R Ridgway, Steven A Chance, Giacomo Koch
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引用次数: 0
摘要
阿尔茨海默病（AD）的特征是涉及默认模式网络（DMN）的结构和功能障碍，而楔前神经元（PC）是该网络的一个关键节点。我们提出了一项随机双盲试验研究，以确定轻度至中度 AD 患者接受 24 周 PC-rTMS 治疗后的神经生物学变化。16名患者被随机分配到SHAM或PC-rTMS，接受为期2周的强化治疗，每天进行经颅磁刺激治疗，随后进入维持阶段，每周进行一次经颅磁刺激治疗。在治疗前后，我们收集了结构性和功能性磁共振成像。我们的研究结果表明，治疗 24 周后，PC-rTMS 组与 SHAM-rTMS 组相比，PC-rTMS 组的宏观和微观结构都得到了保护，这与 PC-rTMS 组 PC 内部功能连接性（FC）的增加有关。即使是初步研究，这些结果也为使用 PC-rTMS 通过操纵分布式网络连接模式来阻止萎缩进展提供了可能性。
Macro and micro structural preservation of grey matter integrity after 24 weeks of rTMS in Alzheimer's disease patients: a pilot study.
Alzheimer's Disease (AD) is characterized by structural and functional dysfunction involving the Default Mode Network (DMN), for which the Precuneus (PC) is a key node. We proposed a randomized double-blind pilot study to determine neurobiological changes after 24 weeks of PC-rTMS in patients with mild-to-moderate AD. Sixteen patients were randomly assigned to SHAM or PC-rTMS, and received an intensive 2-weeks course with daily rTMS sessions, followed by a maintenance phase in which rTMS has been applied once a week. Before and after the treatment structural and functional MRIs were collected. Our results showed macro- and micro-structural preservation in PC-rTMS compared to SHAM-rTMS group after 24 weeks of treatment, correlated to an increase of functional connectivity (FC) within the PC in the PC-rTMS group. Even if preliminary, these results trigger the possibility of using PC-rTMS to arrest atrophy progression by manipulating distributed network connectivity patterns.
期刊介绍：
Alzheimer's Research & Therapy is an international peer-reviewed journal that focuses on translational research into Alzheimer's disease and other neurodegenerative diseases. It publishes open-access basic research, clinical trials, drug discovery and development studies, and epidemiologic studies. The journal also includes reviews, viewpoints, commentaries, debates, and reports. All articles published in Alzheimer's Research & Therapy are included in several reputable databases such as CAS, Current contents, DOAJ, Embase, Journal Citation Reports/Science Edition, MEDLINE, PubMed, PubMed Central, Science Citation Index Expanded (Web of Science) and Scopus.
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