母乳喂养时间可降低儿童患白血病的风险并改变患功能性胃肠病的风险。

IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Breastfeeding Medicine Pub Date : 2024-07-01 Epub Date: 2024-07-05 DOI:10.1089/bfm.2024.0033
Abdulbari Bener, Mahmut Tokaç, Ihab Tewfik, Susu M Zughaier, Ahmet Faruk Ağan, Andrew S Day
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Most (<i>n</i> = 189; 56.6%) of the children with leukemia were <10 years of age. Differences between cases and controls included the duration of breastfeeding (<i>p</i> < 0.0001), mean birthweight (<i>p</i> < 0.001), maternal age (<i>p</i> < 0.001), paternal age (<i>p</i> < 0.001), birth order (<i>p</i> < 0.001), mean number of children (<i>p</i> < 0.001), BMI percentile (<i>p</i> = 0.042), and maternal smoking (<i>p</i> = 0.012). Breastfeeding duration of up to 6 months' duration, when compared with feeding of longer than 6 months, was associated with increased odds ratios (OR) for acute lymphoblastic leukemia (OR = 3.43, 95% confidence interval [CI] 2.37-4.98; <i>p</i> < 0.001), Hodgkin's lymphoma (OR = 1.58, 95% CI: 0.88-2.84, <i>p</i> = 0.120), Non-Hodgkin's lymphoma (OR = 2.14, 95% CI: 1.25-3.65, <i>p</i> = 0.005), and overall (OR = 1.95, 95% CI: 1.40-2.71, <i>p</i> < 0.001). Cases also differed from controls with regard to FGIDs, such as stomach ache (<i>p</i> < 0.001), dyspepsia (<i>p</i> < 0.001), early satiety (<i>p</i> = 0.017), bowel satisfaction (<i>p</i> < 0.001), bloating (<i>p</i> < 0.001), nausea (<i>p</i> = 0.005), vomiting (<i>p</i> = 0.039), constipation (<i>p</i> = 0.003), diarrhea (<i>p</i> = 0.010), gastrointestinal canal congestion (<i>p</i> =0.039), muscle aches pains (<i>p</i> = 0.008), fecal incontinence (<i>p</i> = 0.021), and indigestion (<i>p</i> = 0.003). A multivariate stepwise regression analysis revealed that maternal smoking (<i>p</i> < 0.001), formula feeding (<i>p</i> < 0.001), duration of breastfeeding (<i>p</i> < 0.001), birth order (<i>p</i> = 0.002), mother's age (<i>p</i> = 0.004) and the child's birthweight (<i>p</i> = 0.009) were predictors for leukemia. Further analysis showed that dyspepsia (<i>p</i> < 0.001), gastrointestinal tract canal congestion (<i>p</i> < 0.001), constipation (<i>p</i> = 0.009), diarrhea (<i>p</i> = 0.013), bowel satisfaction (<i>p</i> = 0.021), bloating (<i>p</i> = 0.022), duration of breastfeeding (<i>p</i> < 0.001), and stomach ache (<i>p</i> = 0.025) were significant predictors for developing FGID symptoms after adjusting for age, gender, and other confounding variables. <b><i>Conclusion</i></b>: This study confirmed that breastfeeding has some effect on reducing possible risk of childhood lymphoma and leukemia and FGID symptoms compared with healthy control children.</p>","PeriodicalId":9142,"journal":{"name":"Breastfeeding Medicine","volume":" ","pages":"539-546"},"PeriodicalIF":2.1000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Breastfeeding Duration Reduces the Risk of Childhood Leukemia and Modifies the Risk of Developing Functional Gastrointestinal Disorders.\",\"authors\":\"Abdulbari Bener, Mahmut Tokaç, Ihab Tewfik, Susu M Zughaier, Ahmet Faruk Ağan, Andrew S Day\",\"doi\":\"10.1089/bfm.2024.0033\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b><i>Objective</i></b>: The aim of this study was to test the hypothesis that the duration of breastfeeding in infancy reduces the risk of childhood leukemia or lymphoma, and modifies the risk of developing functional gastrointestinal disorders (FGIDs). <b><i>Subjects and Methods:</i></b> This case-control study involved the recruitment of children with lymphoid malignancy and functional gastrointestinal symptoms with healthy children as controls. 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引用次数: 0

摘要

研究目的本研究旨在验证以下假设:婴儿期母乳喂养的持续时间可降低儿童白血病或淋巴瘤的患病风险,并可改变患功能性胃肠道疾病(FGIDs)的风险。研究对象和方法:这项病例对照研究招募了患有淋巴恶性肿瘤和功能性胃肠道症状的儿童,并以健康儿童作为对照。采用重点问卷调查法收集有关母乳喂养史和其他主要风险因素的数据。进行了单变量和多变量分析。研究结果在334名淋巴恶性肿瘤患儿中,65%为男性。对照组包括 334 名年龄和性别匹配的参与者。大多数白血病患儿(n = 189;56.6%)的出生体重(p < 0.0001)、平均出生体重(p < 0.001)、母亲年龄(p < 0.001)、父亲年龄(p < 0.001)、出生顺序(p < 0.001)、平均子女数(p < 0.001)、体重指数百分位数(p = 0.042)和母亲吸烟(p = 0.012)均低于对照组。与喂养时间超过 6 个月的母乳喂养相比,喂养时间不超过 6 个月的母乳喂养与急性淋巴细胞白血病的几率比(OR)增加有关(OR = 3.43,95% 置信区间 [CI] 2.37-4.98;p < 0.001)、霍奇金淋巴瘤(OR = 1.58,95% CI:0.88-2.84,p = 0.120)、非霍奇金淋巴瘤(OR = 2.14,95% CI:1.25-3.65,p = 0.005)和总体(OR = 1.95,95% CI:1.40-2.71,p < 0.001)。在胃痛(p < 0.001)、消化不良(p < 0.001)、早饱(p = 0.017)、肠道满意度(p < 0.001)、腹胀(p < 0.001)、恶心(p = 0.005)、呕吐(p = 0.039)、便秘(p = 0.003)、腹泻(p = 0.010)、胃肠道充血(p = 0.039)、肌肉酸痛(p = 0.008)、大便失禁(p = 0.021)和消化不良(p = 0.003)。多变量逐步回归分析显示,母亲吸烟(p < 0.001)、配方奶喂养(p < 0.001)、母乳喂养时间(p < 0.001)、出生顺序(p = 0.002)、母亲年龄(p = 0.004)和婴儿出生体重(p = 0.009)是白血病的预测因素。进一步分析表明,消化不良(p < 0.001)、胃肠道管充血(p < 0.001)、便秘(p = 0.009)、腹泻(p = 0.013)、排便满意度(p = 0.021)、腹胀(p = 0.022)、母乳喂养持续时间(p < 0.001)和胃痛(p = 0.025)是在调整年龄、性别和其他混杂变量后出现 FGID 症状的重要预测因素。结论本研究证实,与健康对照组儿童相比,母乳喂养对降低儿童淋巴瘤、白血病和 FGID 症状的可能风险有一定作用。
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Breastfeeding Duration Reduces the Risk of Childhood Leukemia and Modifies the Risk of Developing Functional Gastrointestinal Disorders.

Objective: The aim of this study was to test the hypothesis that the duration of breastfeeding in infancy reduces the risk of childhood leukemia or lymphoma, and modifies the risk of developing functional gastrointestinal disorders (FGIDs). Subjects and Methods: This case-control study involved the recruitment of children with lymphoid malignancy and functional gastrointestinal symptoms with healthy children as controls. Focused questionnaires were used to collect data on breastfeeding history and other key risk factors. Univariate and multivariate analyses were undertaken. Results: Of the 334 children with lymphoid malignancy, 65% were male. The control group included 334 age- and sex-matched participants. Most (n = 189; 56.6%) of the children with leukemia were <10 years of age. Differences between cases and controls included the duration of breastfeeding (p < 0.0001), mean birthweight (p < 0.001), maternal age (p < 0.001), paternal age (p < 0.001), birth order (p < 0.001), mean number of children (p < 0.001), BMI percentile (p = 0.042), and maternal smoking (p = 0.012). Breastfeeding duration of up to 6 months' duration, when compared with feeding of longer than 6 months, was associated with increased odds ratios (OR) for acute lymphoblastic leukemia (OR = 3.43, 95% confidence interval [CI] 2.37-4.98; p < 0.001), Hodgkin's lymphoma (OR = 1.58, 95% CI: 0.88-2.84, p = 0.120), Non-Hodgkin's lymphoma (OR = 2.14, 95% CI: 1.25-3.65, p = 0.005), and overall (OR = 1.95, 95% CI: 1.40-2.71, p < 0.001). Cases also differed from controls with regard to FGIDs, such as stomach ache (p < 0.001), dyspepsia (p < 0.001), early satiety (p = 0.017), bowel satisfaction (p < 0.001), bloating (p < 0.001), nausea (p = 0.005), vomiting (p = 0.039), constipation (p = 0.003), diarrhea (p = 0.010), gastrointestinal canal congestion (p =0.039), muscle aches pains (p = 0.008), fecal incontinence (p = 0.021), and indigestion (p = 0.003). A multivariate stepwise regression analysis revealed that maternal smoking (p < 0.001), formula feeding (p < 0.001), duration of breastfeeding (p < 0.001), birth order (p = 0.002), mother's age (p = 0.004) and the child's birthweight (p = 0.009) were predictors for leukemia. Further analysis showed that dyspepsia (p < 0.001), gastrointestinal tract canal congestion (p < 0.001), constipation (p = 0.009), diarrhea (p = 0.013), bowel satisfaction (p = 0.021), bloating (p = 0.022), duration of breastfeeding (p < 0.001), and stomach ache (p = 0.025) were significant predictors for developing FGID symptoms after adjusting for age, gender, and other confounding variables. Conclusion: This study confirmed that breastfeeding has some effect on reducing possible risk of childhood lymphoma and leukemia and FGID symptoms compared with healthy control children.

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来源期刊
Breastfeeding Medicine
Breastfeeding Medicine OBSTETRICS & GYNECOLOGY-PEDIATRICS
CiteScore
4.20
自引率
11.10%
发文量
130
审稿时长
6-12 weeks
期刊介绍: Breastfeeding Medicine provides unparalleled peer-reviewed research, protocols, and clinical applications to ensure optimal care for mother and infant. The Journal answers the growing demand for evidence-based research and explores the immediate and long-term outcomes of breastfeeding, including its epidemiologic, physiologic, and psychological benefits. It is the exclusive source of the Academy of Breastfeeding Medicine protocols. Breastfeeding Medicine coverage includes: Breastfeeding recommendations and protocols Health consequences of artificial feeding Physiology of lactation and biochemistry of breast milk Optimal nutrition for the breastfeeding mother Breastfeeding indications and contraindications Managing breastfeeding discomfort, pain, and other complications Breastfeeding the premature or sick infant Breastfeeding in the chronically ill mother Management of the breastfeeding mother on medication Infectious disease transmission through breast milk and breastfeeding The collection and storage of human milk and human milk banking Measuring the impact of being a “baby-friendly” hospital Cultural competence and cultural sensitivity International public health issues including social and economic issues.
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