成人星形胶质瘤的细胞外基质结构及与免疫细胞的相互作用

IF 3.6 4区 医学 Q3 CELL BIOLOGY Cellular and Molecular Neurobiology Pub Date : 2024-07-05 DOI:10.1007/s10571-024-01488-z
Anna Di Vito, Annalidia Donato, Jessica Bria, Francesco Conforti, Domenico La Torre, Natalia Malara, Giuseppe Donato
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引用次数: 0

摘要

细胞外基质(ECM)是由胚胎和成人正常和病理组织的细胞成分产生的一组动态分子。ECM 在分化、细胞增殖、血管生成和免疫控制等各种生物过程中起着重要的调节作用。最常见的原发性脑肿瘤是胶质瘤,其中绝大多数是成人星形胶质细胞瘤(AAT)。这些肿瘤患者的预后很差,而治疗方法只能适度提高生存率。文献中有关 AATs 中 ECM 组成的研究相当多,而有关 ECM 组成与免疫调节的研究则较少。循环 ECM 蛋白已成为一种很有前景的生物标志物,它能反映肿瘤微环境的总体免疫状况,并可能成为评估疾病活动的有用工具。鉴于其对治疗和预后的重要性,我们的研究旨在总结 ECM 成分的生物学特性及其对肿瘤微环境的影响,并概述 AATs 中主要 ECM 蛋白和免疫细胞之间的相互作用。随着胶质瘤免疫疗法领域的迅速扩展,我们认为目前的数据以及未来对胶质瘤中 ECM 组织和功能的研究将为调整免疫疗法方法提供重要见解。
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Extracellular Matrix Structure and Interaction with Immune Cells in Adult Astrocytic Tumors.

The extracellular matrix (ECM) is a dynamic set of molecules produced by the cellular component of normal and pathological tissues of the embryo and adult. ECM acts as critical regulator in various biological processes such as differentiation, cell proliferation, angiogenesis, and immune control. The most frequent primary brain tumors are gliomas and by far the majority are adult astrocytic tumors (AATs). The prognosis for patients with these neoplasms is poor and the treatments modestly improves survival. In the literature, there is a fair number of studies concerning the composition of the ECM in AATs, while the number of studies relating the composition of the ECM with the immune regulation is smaller. Circulating ECM proteins have emerged as a promising biomarker that reflect the general immune landscape of tumor microenvironment and may represent a useful tool in assessing disease activity. Given the importance it can have for therapeutic and prognostic purposes, the aim of our study is to summarize the biological properties of ECM components and their effects on the tumor microenvironment and to provide an overview of the interactions between major ECM proteins and immune cells in AATs. As the field of immunotherapy in glioma is quickly expanding, we retain that current data together with future studies on ECM organization and functions in glioma will provide important insights into the tuning of immunotherapeutic approaches.

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来源期刊
CiteScore
7.70
自引率
0.00%
发文量
137
审稿时长
4-8 weeks
期刊介绍: Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.
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