骨质疏松症和阿尔茨海默病（或阿尔茨海默病和骨质疏松症）。

IF 12.5 1区医学 Q1 CELL BIOLOGY Ageing Research Reviews Pub Date : 2024-07-03 DOI:10.1016/j.arr.2024.102408

Nahuel E. Wanionok , Gustavo R. Morel , Juan M. Fernández

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引用次数: 0

摘要

阿尔茨海默病（AD）和骨质疏松症是两种主要影响老年人的疾病，随着预期寿命的延长，这两种疾病的发病率也在增加。一些流行病学研究表明，这两种疾病之间存在相互关联，发现阿尔茨海默病患者的骨质疏松症发病率增加，而骨质疏松症患者的阿尔茨海默病负担更高。这种流行病学关系促使人们寻找与这两种疾病相关的分子、基因、信号传导途径和机制。这些研究中发现的机制可用于改善治疗方法和制定更好的患者护理方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Osteoporosis and Alzheimer´s disease (or Alzheimer´s disease and Osteoporosis)

Alzheimer's disease (AD) and osteoporosis are two diseases that mainly affect elderly people, with increases in the occurrence of cases due to a longer life expectancy. Several epidemiological studies have shown a reciprocal association between both diseases, finding an increase in incidence of osteoporosis in patients with AD, and a higher burden of AD in osteoporotic patients. This epidemiological relationship has motivated the search for molecules, genes, signaling pathways and mechanisms that are related to both pathologies. The mechanisms found in these studies can serve to improve treatments and establish better patient care protocols.

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.