从盐肤木种子中提取的二聚哌啶喹啉生物碱

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL Phytochemistry Letters Pub Date : 2024-07-04 DOI:10.1016/j.phytol.2024.07.001

Zhan-Peng Yu , Yu-Xia Wang , Li-Hong Hong , Ya-Lin Li , Jian-Fei Zhang , Mu Li , Ping Ying , Qiang Zheng , Ling-Yi Kong , Jian-Guang Luo

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引用次数: 0

摘要

通过对盐肤木种子提取物的化学研究，分离出了四种新的二聚哌啶喹啉生物碱（1-4）和一种新的二聚色胺生物碱（5），以及五种已知生物碱（6-10）。值得注意的是，化合物 3 和 4 被鉴定为两种不同寻常的二聚哌啶喹啉生物碱-脂肪酸杂化物。利用 HRESIMS、NMR 和 ECD 光谱技术阐明了新的结构。分离出的化合物对 HCT-116、HT-1080 和 A549 细胞系进行了细胞毒性测试。化合物 5 对 HCT-116 和 HT-1080 细胞株具有中等活性，IC50 值分别为 44.59 ± 2.08 μM 和 37.39 ± 2.31 μM。

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Dimeric piperidinoquinoline alkaloids from the seeds of Chimonanthus salicifolius

A chemical investigation of extracts from the seeds of Chimonanthus salicifolius has led to the isolation of four new dimeric piperidinoquinoline alkaloids (1-4) and one new dimeric tryptamine alkaloid (5), along with five known alkaloids (6-10). Notably, compounds 3 and 4 were identified as two unusual dimeric piperidinoquinoline alkaloid-fatty acid hybrids. The new structures were elucidated using HRESIMS, NMR, and ECD spectroscopic techniques. The isolated compounds were subjected to cytotoxicity testing against HCT-116, HT-1080, and A549 cell lines. Compound 5 exhibited moderate activity against the HCT-116 and HT-1080 cell lines, with IC₅₀ values of 44.59 ± 2.08 μM and 37.39 ± 2.31 μM, respectively.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.