Seyyed Amir Siadati , Mohammad Ali Ebrahimzadeh , Rezvan Yazdian-Robati , Esmaeil Babanezhad
{"title":"利用α-磷杂菲、g-X3N4 纳米片和 C19X 富勒烯吸附和递送蛋白酶体抑制剂药物的理论方法","authors":"Seyyed Amir Siadati , Mohammad Ali Ebrahimzadeh , Rezvan Yazdian-Robati , Esmaeil Babanezhad","doi":"10.1016/j.diamond.2024.111344","DOIUrl":null,"url":null,"abstract":"<div><p>Bortezomib is a key agent for treatment of cancer; while, it is a very hazardous bioactive substance (for healthy tissues). Therefore, delivering this drug to the targeted cancerous cells by using a suitable carrier is required. Considering it, in this project, several nanosized sorbents containing α-phographene, g-X<sub>3</sub>N<sub>4</sub> nanosheets, and C<sub>19</sub>X fullerenes have been considered for a systematic investigation on the possibility of adsorption and delivering of Bortezomib as a proteasome inhibitor drug residue. The results have indicated that g-B<sub>3</sub>N<sub>4</sub> could be considered as a potential actuator (a nano-sized key) which considerably alters its form by adsorbing Bortezomib (for example in lower temperatures) and returns to its early structure by losing this drug after receiving energy (in relatively higher temperatures). Also, the E<sub>ads</sub> of α-phographene-Bortezomib system is −9.14 kcal mol<sup>−1</sup> which show like some other cases, it might be used for delivering of this drug. Finally, our results confirm that α-Phographene has a relatively good drug recovery time for desorption of Bortezomib (5.13(10<sup>−6</sup>) s at 298.15 K and 2.78(10<sup>−6</sup>) s at the body temperature).</p></div>","PeriodicalId":11266,"journal":{"name":"Diamond and Related Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A theoretical approach on the possibility of using α-phographene, g-X3N4 nanosheets, and C19X fullerenes for adsorption and drug delivery of a proteasome inhibitor drug\",\"authors\":\"Seyyed Amir Siadati , Mohammad Ali Ebrahimzadeh , Rezvan Yazdian-Robati , Esmaeil Babanezhad\",\"doi\":\"10.1016/j.diamond.2024.111344\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Bortezomib is a key agent for treatment of cancer; while, it is a very hazardous bioactive substance (for healthy tissues). Therefore, delivering this drug to the targeted cancerous cells by using a suitable carrier is required. Considering it, in this project, several nanosized sorbents containing α-phographene, g-X<sub>3</sub>N<sub>4</sub> nanosheets, and C<sub>19</sub>X fullerenes have been considered for a systematic investigation on the possibility of adsorption and delivering of Bortezomib as a proteasome inhibitor drug residue. The results have indicated that g-B<sub>3</sub>N<sub>4</sub> could be considered as a potential actuator (a nano-sized key) which considerably alters its form by adsorbing Bortezomib (for example in lower temperatures) and returns to its early structure by losing this drug after receiving energy (in relatively higher temperatures). Also, the E<sub>ads</sub> of α-phographene-Bortezomib system is −9.14 kcal mol<sup>−1</sup> which show like some other cases, it might be used for delivering of this drug. Finally, our results confirm that α-Phographene has a relatively good drug recovery time for desorption of Bortezomib (5.13(10<sup>−6</sup>) s at 298.15 K and 2.78(10<sup>−6</sup>) s at the body temperature).</p></div>\",\"PeriodicalId\":11266,\"journal\":{\"name\":\"Diamond and Related Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-07-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Diamond and Related Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0925963524005570\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, COATINGS & FILMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diamond and Related Materials","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0925963524005570","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, COATINGS & FILMS","Score":null,"Total":0}
A theoretical approach on the possibility of using α-phographene, g-X3N4 nanosheets, and C19X fullerenes for adsorption and drug delivery of a proteasome inhibitor drug
Bortezomib is a key agent for treatment of cancer; while, it is a very hazardous bioactive substance (for healthy tissues). Therefore, delivering this drug to the targeted cancerous cells by using a suitable carrier is required. Considering it, in this project, several nanosized sorbents containing α-phographene, g-X3N4 nanosheets, and C19X fullerenes have been considered for a systematic investigation on the possibility of adsorption and delivering of Bortezomib as a proteasome inhibitor drug residue. The results have indicated that g-B3N4 could be considered as a potential actuator (a nano-sized key) which considerably alters its form by adsorbing Bortezomib (for example in lower temperatures) and returns to its early structure by losing this drug after receiving energy (in relatively higher temperatures). Also, the Eads of α-phographene-Bortezomib system is −9.14 kcal mol−1 which show like some other cases, it might be used for delivering of this drug. Finally, our results confirm that α-Phographene has a relatively good drug recovery time for desorption of Bortezomib (5.13(10−6) s at 298.15 K and 2.78(10−6) s at the body temperature).
期刊介绍:
DRM is a leading international journal that publishes new fundamental and applied research on all forms of diamond, the integration of diamond with other advanced materials and development of technologies exploiting diamond. The synthesis, characterization and processing of single crystal diamond, polycrystalline films, nanodiamond powders and heterostructures with other advanced materials are encouraged topics for technical and review articles. In addition to diamond, the journal publishes manuscripts on the synthesis, characterization and application of other related materials including diamond-like carbons, carbon nanotubes, graphene, and boron and carbon nitrides. Articles are sought on the chemical functionalization of diamond and related materials as well as their use in electrochemistry, energy storage and conversion, chemical and biological sensing, imaging, thermal management, photonic and quantum applications, electron emission and electronic devices.
The International Conference on Diamond and Carbon Materials has evolved into the largest and most well attended forum in the field of diamond, providing a forum to showcase the latest results in the science and technology of diamond and other carbon materials such as carbon nanotubes, graphene, and diamond-like carbon. Run annually in association with Diamond and Related Materials the conference provides junior and established researchers the opportunity to exchange the latest results ranging from fundamental physical and chemical concepts to applied research focusing on the next generation carbon-based devices.