Karen A. Lawrence , Elana M. Gloger , Cristina N. Pinheiro , Frederick A. Schmitt , Suzanne C. Segerstrom
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引用次数: 0
摘要
炎症与阿尔茨海默病(AD)有关,炎症细胞因子基因中的特定单核苷酸多态性(SNPs)与阿尔茨海默病风险的增加有关。同样的多态性是否也能预测认知健康的老年人特定领域的认知变化尚不清楚。我们在 324 位非痴呆老年人样本中评估了 IL-1β (rs16944)、IL-6 (rs1800795) 和 TNFα (rs1800629) 这三个细胞因子基因中的特定 SNP 与长达 16 年的整体认知功能、外显记忆、注意力和工作记忆以及执行功能的纵向轨迹的相关性。随着时间的推移,只有 rs1800629(TNFα)与整体认知功能的显著变化相关[γ = 5.22; 95% CI: 0.61, 9.83; p = 0.027]。尽管 rs16944 和 rs1800795 与注意力缺失症风险有关,但它们可能无法预测认知健康的老年人的认知能力下降。随着时间的推移,rs1800629(TNFα)上的 A 可能会对认知功能产生广泛的保护作用。需要进行更多的验证研究,以确定特定的细胞因子 SNP 是否与各自的血清水平相关,从而进一步了解也可作为认知功能下降标志物的 AD 生物标志物。
Associations between IL-1β, IL-6, and TNFα polymorphisms and longitudinal trajectories of cognitive function in non-demented older adults
Inflammation is implicated in Alzheimer's disease (AD), and specific single nucleotide polymorphisms (SNPs) in inflammatory cytokine genes are associated with increased AD risk. Whether the same polymorphisms also predict domain-specific cognitive change in cognitively healthy older adults is unclear. Specific SNPs in three cytokine genes, IL-1β (rs16944), IL-6 (rs1800795), and TNFα (rs1800629) were assessed for association with longitudinal trajectories spanning up to 16 years of global cognitive function, episodic memory, attention and working memory, and executive function in a sample of 324 non-demented older adults. Only rs1800629 (TNFα) was associated with significant change in global cognitive function over time [γ = 5.22; 95% CI: 0.61, 9.83; p = 0.027]. Despite an association with AD risk, rs16944 and rs1800795 may not predict cognitive decline in cognitively healthy older adults. The presence of an A at rs1800629 (TNFα) may have broad, protective effects on cognitive function, over time. More validation studies are needed to determine whether specific cytokine SNPs are associated with respective serum levels to further understanding of AD biomarkers that may also serve as markers of cognitive decline.