药物疗法作为肥胖症减肥手术的辅助手段。

IF 13 1区 医学 Q1 PHARMACOLOGY & PHARMACY Drugs Pub Date : 2024-08-01 Epub Date: 2024-07-06 DOI:10.1007/s40265-024-02029-0
Luděk Horváth, Miloš Mráz, Edward B Jude, Martin Haluzík
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引用次数: 0

摘要

由于肥胖症与 2 型糖尿病、动脉高血压、血脂异常、心力衰竭、癌症等多种并发症密切相关,全球肥胖症大流行是全球最重大的健康威胁之一。肥胖症及其并发症会导致心血管并发症、心力衰竭的发生率升高,并增加心血管疾病和整体死亡率。减肥手术是目前治疗肥胖症最有效的方法,可使大多数患者的体重明显减轻。从长期来看,减肥手术后相当一部分患者的体重会逐渐恢复,有些患者的体重可能会达到手术前的水平。因此,一些患者在减肥手术后可能需要进行抗肥胖药物治疗,以防止体重反弹或进一步促进体重减轻。本文概述了使用抗肥胖药物作为肥胖症减肥手术的辅助疗法。尽管已发表的数据相对有限,但可以得出结论,抗肥胖药物可作为减肥手术的有效辅助疗法,帮助促进减肥手术后的体重减轻或防止体重反弹。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Pharmacotherapy as an Augmentation to Bariatric Surgery for Obesity.

A global obesity pandemic is one of the most significant health threats worldwide owing to its close association with numerous comorbidities such as type 2 diabetes mellitus, arterial hypertension, dyslipidemia, heart failure, cancer and many others. Obesity and its comorbidities lead to a higher rate of cardiovascular complications, heart failure and increased cardiovascular and overall mortality. Bariatric surgery is at present the most potent therapy for obesity, inducing a significant weight loss in the majority of patients. In the long-term, a substantial proportion of patients after bariatric surgery experience a gradual weight regain that may, in some, reach up to a presurgical body weight. As a result, anti-obesity pharmacotherapy may be needed in some patients after bariatric surgery to prevent the weight regain or to further potentiate weight loss. This article provides an overview of the use of anti-obesity medications as an augmentation to bariatric surgery for obesity. Despite relatively limited published data, it can be concluded that anti-obesity medication can serve as an effective adjunct therapy to bariatric surgery to help boost post-bariatric weight loss or prevent weight regain.

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来源期刊
Drugs
Drugs 医学-毒理学
CiteScore
22.70
自引率
0.90%
发文量
134
审稿时长
3-8 weeks
期刊介绍: Drugs is a journal that aims to enhance pharmacotherapy by publishing review and original research articles on key aspects of clinical pharmacology and therapeutics. The journal includes: Leading/current opinion articles providing an overview of contentious or emerging issues. Definitive reviews of drugs and drug classes, and their place in disease management. Therapy in Practice articles including recommendations for specific clinical situations. High-quality, well designed, original clinical research. Adis Drug Evaluations reviewing the properties and place in therapy of both newer and established drugs. AdisInsight Reports summarising development at first global approval. Moreover, the journal offers additional digital features such as animated abstracts, video abstracts, instructional videos, and podcasts to increase visibility and educational value. Plain language summaries accompany articles to assist readers with some knowledge of the field in understanding important medical advances.
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