Chenyu Zhu , Lingli Zhang , Xiaoqing Ding , Wei Wu , Jun Zou
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引用次数: 0
摘要
骨关节炎(OA)是一种慢性退行性关节疾病,有多种致病因素,如衰老、机械损伤和肥胖。自噬是一个复杂的动态过程,在不同的病理生理条件下参与细胞内蛋白质和细胞器的降解和修饰。自噬作为各种应激条件下的一种细胞生存机制,在调节软骨细胞生命周期代谢和细胞稳态方面发挥着关键作用。非编码 RNA(ncRNA)是不具有蛋白质编码功能的异质性转录本,但它们可以作为基因和蛋白质表达的有效转录后和表观遗传调节因子,从而参与许多基本生物过程。越来越多的证据表明,ncRNA、自噬及其相互作用在 OA 发病机制中起着至关重要的作用。因此,我们总结了自噬在OA软骨细胞中的复杂作用,重点研究了ncRNA在OA相关自噬中的调控作用,以阐明ncRNA-自噬网络在OA发病中的复杂病理机制,从而为OA的临床诊断和治疗提供新的研究靶点。
Non-coding RNAs as regulators of autophagy in chondrocytes: Mechanisms and implications for osteoarthritis
Osteoarthritis (OA) is a chronic degenerative joint disease with multiple causative factors such as aging, mechanical injury, and obesity. Autophagy is a complex dynamic process that is involved in the degradation and modification of intracellular proteins and organelles under different pathophysiological conditions. Autophagy, as a cell survival mechanism under various stress conditions, plays a key role in regulating chondrocyte life cycle metabolism and cellular homeostasis. Non-coding RNAs (ncRNAs) are heterogeneous transcripts that do not possess protein-coding functions, but they can act as effective post-transcriptional and epigenetic regulators of gene and protein expression, thus participating in numerous fundamental biological processes. Increasing evidence suggests that ncRNAs, autophagy, and their crosstalk play crucial roles in OA pathogenesis. Therefore, we summarized the complex role of autophagy in OA chondrocytes and focused on the regulatory role of ncRNAs in OA-associated autophagy to elucidate the complex pathological mechanisms of the ncRNA-autophagy network in the development of OA, thus providing new research targets for the clinical diagnosis and treatment of OA.
期刊介绍:
With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends.
ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research.
The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.