组蛋白去乙酰化酶复合物:结构、调节和功能

IF 9.7 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-07-04 DOI:10.1016/j.bbcan.2024.189150
Moges Dessale Asmamaw , Ang He , Li-Rong Zhang , Hong-Min Liu , Ya Gao
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引用次数: 0

摘要

组蛋白去乙酰化酶(HDAC)是关键的表观遗传调控因子,具有去乙酰化酶功能的转录复合物是细胞核中针对表观基因组的表观遗传核心抑制复合物之一。带有 HDAC 的核心抑制复合体,如 Sin3 复合体、NuRD 复合体、CoREST 复合体和 SMRT/NCoR 复合体,在生物系统中很常见。这些复合体能以单独状态激活原本不活跃的 HDAC。HDAC 复合物在转录、复制和 DNA 修复等关键生物过程的调控中发挥着重要作用。此外,HDAC 复合物功能失调还与包括癌症在内的人类疾病有关。目前正在积极寻找针对 HDAC 复合物的治疗策略。因此,说明 HDAC 复合物的性质和组成对于了解它们在生理和病理条件下发挥功能的分子基础以及设计靶向疗法至关重要。本综述介绍了大型多蛋白 HDAC 复合物的主要方面,包括其结构、功能、调控机制、在疾病发展中的影响以及在治疗中的作用。
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Histone deacetylase complexes: Structure, regulation and function

Histone deacetylases (HDACs) are key epigenetic regulators, and transcriptional complexes with deacetylase function are among the epigenetic corepressor complexes in the nucleus that target the epigenome. HDAC-bearing corepressor complexes such as the Sin3 complex, NuRD complex, CoREST complex, and SMRT/NCoR complex are common in biological systems. These complexes activate the otherwise inactive HDACs in a solitary state. HDAC complexes play vital roles in the regulation of key biological processes such as transcription, replication, and DNA repair. Moreover, deregulated HDAC complex function is implicated in human diseases including cancer. Therapeutic strategies targeting HDAC complexes are being sought actively. Thus, illustration of the nature and composition of HDAC complexes is vital to understanding the molecular basis of their functions under physiologic and pathologic conditions, and for designing targeted therapies. This review presents key aspects of large multiprotein HDAC-bearing complexes including their structure, function, regulatory mechanisms, implication in disease development, and role in therapeutics.

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来源期刊
Biochimica et biophysica acta. Reviews on cancer
Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学
CiteScore
17.20
自引率
0.00%
发文量
138
审稿时长
33 days
期刊介绍: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.
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