Rowan K. H. Brydson , Alan R. Kennedy , F. Di Salvo (Editor)
{"title":"氯噻嗪的单斜多晶型。","authors":"Rowan K. H. Brydson , Alan R. Kennedy , F. Di Salvo (Editor)","doi":"10.1107/S2056989024006078","DOIUrl":null,"url":null,"abstract":"<div><p>Accessible from basic aqueous solutions, a new monoclinic polymorph of the diuretic chlorothiazide is described.</p></div><div><p>A new polymorph of the diuretic chlorothiazide, 6-chloro-1,1-dioxo-2<em>H</em>-1,2,4-benzothiazine-7-sulfonamide, C<sub>7</sub>H<sub>6</sub>ClN<sub>3</sub>O<sub>4</sub>S<sub>2</sub>, is described. Crystallized from basic aqueous solution, this monoclinic polymorph is found to be less thermodynamically favoured than the known triclinic polymorph and to feature only N—H⋯O type intermolecular hydrogen bonds as opposed to the N—H⋯O and N—H⋯N type hydrogen bonds found in the <em>P</em>1 form.</p></div>","PeriodicalId":7367,"journal":{"name":"Acta Crystallographica Section E: Crystallographic Communications","volume":"80 7","pages":"Pages 806-810"},"PeriodicalIF":0.5000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11223696/pdf/","citationCount":"0","resultStr":"{\"title\":\"A monoclinic polymorph of chlorothiazide\",\"authors\":\"Rowan K. H. Brydson , Alan R. Kennedy , F. Di Salvo (Editor)\",\"doi\":\"10.1107/S2056989024006078\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Accessible from basic aqueous solutions, a new monoclinic polymorph of the diuretic chlorothiazide is described.</p></div><div><p>A new polymorph of the diuretic chlorothiazide, 6-chloro-1,1-dioxo-2<em>H</em>-1,2,4-benzothiazine-7-sulfonamide, C<sub>7</sub>H<sub>6</sub>ClN<sub>3</sub>O<sub>4</sub>S<sub>2</sub>, is described. Crystallized from basic aqueous solution, this monoclinic polymorph is found to be less thermodynamically favoured than the known triclinic polymorph and to feature only N—H⋯O type intermolecular hydrogen bonds as opposed to the N—H⋯O and N—H⋯N type hydrogen bonds found in the <em>P</em>1 form.</p></div>\",\"PeriodicalId\":7367,\"journal\":{\"name\":\"Acta Crystallographica Section E: Crystallographic Communications\",\"volume\":\"80 7\",\"pages\":\"Pages 806-810\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11223696/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Crystallographica Section E: Crystallographic Communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S2056989024001336\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CRYSTALLOGRAPHY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Crystallographica Section E: Crystallographic Communications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S2056989024001336","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CRYSTALLOGRAPHY","Score":null,"Total":0}
Accessible from basic aqueous solutions, a new monoclinic polymorph of the diuretic chlorothiazide is described.
A new polymorph of the diuretic chlorothiazide, 6-chloro-1,1-dioxo-2H-1,2,4-benzothiazine-7-sulfonamide, C7H6ClN3O4S2, is described. Crystallized from basic aqueous solution, this monoclinic polymorph is found to be less thermodynamically favoured than the known triclinic polymorph and to feature only N—H⋯O type intermolecular hydrogen bonds as opposed to the N—H⋯O and N—H⋯N type hydrogen bonds found in the P1 form.
期刊介绍：
Acta Crystallographica Section E: Crystallographic Communications is the IUCr''s open-access structural communications journal. It provides a fast, simple and easily accessible publication mechanism for crystal structure determinations of inorganic, metal-organic and organic compounds. The electronic submission, validation, refereeing and publication facilities of the journal ensure rapid and high-quality publication of fully validated structures. The primary article category is Research Communications; these are peer-reviewed articles describing one or more structure determinations with appropriate discussion of the science.
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