尺寸、可变形性和设备布局对微流体中细胞运输的相互作用

IF 2.3 4区 物理与天体物理 Q3 PHYSICS, CONDENSED MATTER Journal of Physics: Condensed Matter Pub Date : 2024-07-25 DOI:10.1088/1361-648X/ad5ff3
Michael C Hood, Karl Gardner, Wei Li, Jifu Tan
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引用次数: 0

摘要

微流控技术已被广泛用于细胞分拣和捕获。在这项工作中,研究人员考虑了细胞尺寸、可变形性和五种不同的装置设计,对微流体装置中的细胞运输进行了数值模拟。 在这五种设计中,确定性横向位移装置(DLD)和超均匀装置(HU)与常规网格、交错和六边形布局设计相比,由于微柱位置不断移动,在促进细胞与微柱碰撞方面表现更好。然而,网格和六角形布局在根据细胞大小的速度区分细胞方面表现最佳,这是因为细胞在流动方向的清晰直道上运输时存在大小排斥效应。对不同无量纲组下的速度分化进行的系统研究表明,速度差异主要由垂直于流动方向的微柱分离距离决定。微流体实验也证实了速度分化的结果。该研究可为微流体设计提供指导原则。
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Interplay of size, deformability, and device layout on cell transport in microfluidics.

Microfluidics have been widely used for cell sorting and capture. In this work, numerical simulations of cell transport in microfluidic devices were studied considering cell sizes, deformability, and five different device designs. Among these five designs, deterministic lateral displacement device (DLD) and hyperuniform device (HU) performed better in promoting cell-micropost collision due to the continuously shifted micropost positions as compared with regular grid, staggered, and hexagonal layout designs. However, the grid and the hexagonal layouts showed best in differentiating cells by their size dependent velocity due to the size exclusion effect for cell transport in clear and straight paths in the flow direction. A systematic study of the velocity differentiation under different dimensionless groups was performed showing that the velocity difference is dominated by the micropost separation distance perpendicular to the direction of flow. Microfluidic experiments also confirmed the velocity differentiation results. The study can provide guiding principles for microfluidic design.

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来源期刊
Journal of Physics: Condensed Matter
Journal of Physics: Condensed Matter 物理-物理:凝聚态物理
CiteScore
5.30
自引率
7.40%
发文量
1288
审稿时长
2.1 months
期刊介绍: Journal of Physics: Condensed Matter covers the whole of condensed matter physics including soft condensed matter and nanostructures. Papers may report experimental, theoretical and simulation studies. Note that papers must contain fundamental condensed matter science: papers reporting methods of materials preparation or properties of materials without novel condensed matter content will not be accepted.
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