Yue Zheng, Haibo Ding, Huaibi Huo, Xin Peng, Jie Zhou, Han Li, Yang Hou, Xiaolin Li, Wenqing Geng, Hong Shang, Ting Liu
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Blood samples for CD4<sup>+</sup> T cells and cardiac risk factors were also collected before MRI.</p><p><strong>Statistical tests: </strong>Independent t tests, Mann-Whitney U test, Pearson's correlation analysis, and multivariate linear analyses (significance level: P < 0.05).</p><p><strong>Results: </strong>PLWH had a significantly larger left atrial volume maximum index (LAVImax: 32.6 ± 8.7 vs. 28.7 ± 8.1 mL/m<sup>2</sup>), minimum (LAVImin: 14.8 ± 5.5 vs. 11.5 ± 5.4 mL/m<sup>2</sup>,), and prior to atrial contraction (LAVIpre-a: 23.4 ± 6.7 vs. 19.7 ± 7.2 mL/m<sup>2</sup>) as compared to healthy volunteers. The LA reservoir (LAtEF: 55.0 ± 10.2 vs. 61.4 ± 10.4; Sls: 29.0 ± 8.1 vs. 33.8 ± 11.8), conduit (LApEF: 28.4 ± 8.2 vs. 32.3 ± 11.3, P = 0.01; Sle: 16.3 ± 6.5 vs. 18.9 ± 8.2), and booster pump function (LAaEF: 37.4 ± 12.4 vs. 42.7 ± 13.1, P = 0.01, Sla: 12.7 ± 5.1 vs. 14.9 ± 5.7) were all significant impaired in PLWH. Global circumferential left ventricular diastolic strain rate (LVGCS-d) was significantly lower in the HIV patients. Multivariate analysis results showed that Nadir CD4<sup>+</sup> T cells had a significant adverse association with LVGCS-d (β = 0.51).</p><p><strong>Conclusion: </strong>LA structure abnormalities and LV diastolic dysfunction were manifested in PLWH, with Nadir CD4+ T cell counts potentially serving as a risk factor for early cardiac diastolic dysfunction.</p><p><strong>Level of evidence: </strong>2 TECHNICAL EFFICACY: Stage 3.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"MRI Assessment of Diastolic Dysfunction in People Living With the Human Immunodeficiency Virus: Correlation With Markers of Disease Activity.\",\"authors\":\"Yue Zheng, Haibo Ding, Huaibi Huo, Xin Peng, Jie Zhou, Han Li, Yang Hou, Xiaolin Li, Wenqing Geng, Hong Shang, Ting Liu\",\"doi\":\"10.1002/jmri.29503\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Despite the advent of combination antiretroviral therapy, people living with human immunodeficiency virus (PLWH) are at an increased risk for cardiac disease.</p><p><strong>Purpose: </strong>To explore the presence and extent of diastolic atrial and left ventricular dysfunction in PLWH using cardiac MRI in correlation with clinical markers of disease activity.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Population: </strong>A total of 163 participants comprising 101 HIV-infected individuals (age: 52 years [42-62 years]; 92% male) and 62 age- and sex-matched healthy volunteers (age: 51 years [30-72 years]; 85% male).</p><p><strong>Field strength/sequence: </strong>3.0 T, cardiac MRI including balanced steady-state free precession (SSFP) for the short-axis, two-, three-, and four-chamber views were performed.</p><p><strong>Assessment: </strong>Assessment of cardiac function and strain analysis were accomplished by CVI42 software. Blood samples for CD4<sup>+</sup> T cells and cardiac risk factors were also collected before MRI.</p><p><strong>Statistical tests: </strong>Independent t tests, Mann-Whitney U test, Pearson's correlation analysis, and multivariate linear analyses (significance level: P < 0.05).</p><p><strong>Results: </strong>PLWH had a significantly larger left atrial volume maximum index (LAVImax: 32.6 ± 8.7 vs. 28.7 ± 8.1 mL/m<sup>2</sup>), minimum (LAVImin: 14.8 ± 5.5 vs. 11.5 ± 5.4 mL/m<sup>2</sup>,), and prior to atrial contraction (LAVIpre-a: 23.4 ± 6.7 vs. 19.7 ± 7.2 mL/m<sup>2</sup>) as compared to healthy volunteers. The LA reservoir (LAtEF: 55.0 ± 10.2 vs. 61.4 ± 10.4; Sls: 29.0 ± 8.1 vs. 33.8 ± 11.8), conduit (LApEF: 28.4 ± 8.2 vs. 32.3 ± 11.3, P = 0.01; Sle: 16.3 ± 6.5 vs. 18.9 ± 8.2), and booster pump function (LAaEF: 37.4 ± 12.4 vs. 42.7 ± 13.1, P = 0.01, Sla: 12.7 ± 5.1 vs. 14.9 ± 5.7) were all significant impaired in PLWH. Global circumferential left ventricular diastolic strain rate (LVGCS-d) was significantly lower in the HIV patients. Multivariate analysis results showed that Nadir CD4<sup>+</sup> T cells had a significant adverse association with LVGCS-d (β = 0.51).</p><p><strong>Conclusion: </strong>LA structure abnormalities and LV diastolic dysfunction were manifested in PLWH, with Nadir CD4+ T cell counts potentially serving as a risk factor for early cardiac diastolic dysfunction.</p><p><strong>Level of evidence: </strong>2 TECHNICAL EFFICACY: Stage 3.</p>\",\"PeriodicalId\":16140,\"journal\":{\"name\":\"Journal of Magnetic Resonance Imaging\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-07-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Magnetic Resonance Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/jmri.29503\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Magnetic Resonance Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jmri.29503","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
摘要
背景：目的：利用心脏核磁共振成像技术，探讨人类免疫缺陷病毒感染者舒张期心房和左心室功能障碍的存在和程度，并将其与疾病活动的临床指标联系起来：研究类型：前瞻性：共163名参与者，包括101名HIV感染者（年龄：52岁[42-62岁]；92%为男性）和62名年龄和性别匹配的健康志愿者（年龄：51岁[30-72岁]；85%为男性）：场强/序列：3.0 T，心脏磁共振成像，包括短轴、两腔、三腔和四腔切面的平衡稳态自由前冲（SSFP）：评估：心脏功能评估和应变分析由 CVI42 软件完成。核磁共振成像前还采集了血液样本，以检测 CD4+ T 细胞和心脏风险因素：统计检验：独立 t 检验、曼-惠特尼 U 检验、皮尔逊相关分析和多变量线性分析（显著性水平：P）：结果：P与健康志愿者相比，PLWH 的左心房容积最大指数（LAVImax：32.6 ± 8.7 vs. 28.7 ± 8.1 mL/m2）、最小指数（LAVImin：14.8 ± 5.5 vs. 11.5 ± 5.4 mL/m2）和心房收缩前指数（LAVIpre-a：23.4 ± 6.7 vs. 19.7 ± 7.2 mL/m2）均明显增大。37.4 ± 12.4 vs. 42.7 ± 13.1，P = 0.01；Sla：12.7±5.1对14.9±5.7）均明显受损。艾滋病患者的左心室舒张期全周应变率（LVGCS-d）明显较低。多变量分析结果显示，Nadir CD4+ T细胞与LVGCS-d有明显的负相关（β = 0.51）：LA结构异常和左心室舒张功能障碍在艾滋病病毒感染者中有所表现，CD4+T细胞纳底计数可能是早期心脏舒张功能障碍的危险因素。
MRI Assessment of Diastolic Dysfunction in People Living With the Human Immunodeficiency Virus: Correlation With Markers of Disease Activity.
Background: Despite the advent of combination antiretroviral therapy, people living with human immunodeficiency virus (PLWH) are at an increased risk for cardiac disease.
Purpose: To explore the presence and extent of diastolic atrial and left ventricular dysfunction in PLWH using cardiac MRI in correlation with clinical markers of disease activity.
Study type: Prospective.
Population: A total of 163 participants comprising 101 HIV-infected individuals (age: 52 years [42-62 years]; 92% male) and 62 age- and sex-matched healthy volunteers (age: 51 years [30-72 years]; 85% male).
Field strength/sequence: 3.0 T, cardiac MRI including balanced steady-state free precession (SSFP) for the short-axis, two-, three-, and four-chamber views were performed.
Assessment: Assessment of cardiac function and strain analysis were accomplished by CVI42 software. Blood samples for CD4+ T cells and cardiac risk factors were also collected before MRI.
Statistical tests: Independent t tests, Mann-Whitney U test, Pearson's correlation analysis, and multivariate linear analyses (significance level: P < 0.05).
Results: PLWH had a significantly larger left atrial volume maximum index (LAVImax: 32.6 ± 8.7 vs. 28.7 ± 8.1 mL/m2), minimum (LAVImin: 14.8 ± 5.5 vs. 11.5 ± 5.4 mL/m2,), and prior to atrial contraction (LAVIpre-a: 23.4 ± 6.7 vs. 19.7 ± 7.2 mL/m2) as compared to healthy volunteers. The LA reservoir (LAtEF: 55.0 ± 10.2 vs. 61.4 ± 10.4; Sls: 29.0 ± 8.1 vs. 33.8 ± 11.8), conduit (LApEF: 28.4 ± 8.2 vs. 32.3 ± 11.3, P = 0.01; Sle: 16.3 ± 6.5 vs. 18.9 ± 8.2), and booster pump function (LAaEF: 37.4 ± 12.4 vs. 42.7 ± 13.1, P = 0.01, Sla: 12.7 ± 5.1 vs. 14.9 ± 5.7) were all significant impaired in PLWH. Global circumferential left ventricular diastolic strain rate (LVGCS-d) was significantly lower in the HIV patients. Multivariate analysis results showed that Nadir CD4+ T cells had a significant adverse association with LVGCS-d (β = 0.51).
Conclusion: LA structure abnormalities and LV diastolic dysfunction were manifested in PLWH, with Nadir CD4+ T cell counts potentially serving as a risk factor for early cardiac diastolic dysfunction.
期刊介绍：
The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.
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