解决拉沙热治疗瓶颈:克服利巴韦林肠外制剂的挑战。

IF 3.6 Q1 TROPICAL MEDICINE Tropical Medicine and Health Pub Date : 2024-07-08 DOI:10.1186/s41182-024-00609-0
Qudus Olajide Lawal, Joseph Okoeguale, Sebastine Oseghae Oiwoh, ThankGod Akhigbe, Reuben Agbons Eifediyi, Sylvanus Akhalufo Okogbenin
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引用次数: 0

摘要

利巴韦林安瓿制剂仍然是治疗拉沙热疾病的一大挑战。拉沙热是西非次区域的一种地方性病毒性出血热,其治疗标准是大剂量利巴韦林。由于需要大剂量治疗,因此 200 毫克/毫升安瓿剂量的利巴韦林是一项艰巨的任务,尤其是在疾病爆发期间。本评论强调了这一挑战,并热情呼吁调整安瓿剂量,以适应拉沙热疾病的大剂量要求。
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Addressing bottlenecks in Lassa fever treatment: overcoming the ribavirin parenteral formulation challenge.

Ribavirin ampoule formulation remains a major challenge in managing Lassa fever disease. Lassa fever is an endemic viral hemorrhagic fever in the West Africa subregion, which has high-dose ribavirin as the standard of care. The high-dose therapy required makes the 200 mg/ml ampoule dosing of ribavirin a daunting task to administer, especially during disease outbreaks. This commentary highlights the challenges and makes a passionate call for vial dosage adjustment to fit the high-dose requirement of Lassa fever disease.

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来源期刊
Tropical Medicine and Health
Tropical Medicine and Health TROPICAL MEDICINE-
CiteScore
7.00
自引率
2.20%
发文量
90
审稿时长
11 weeks
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