苯基硼酸官能化透明质酸作为多糖载体用于含二醇药物的输送

IF 2.8 4区 化学 Q1 CHEMISTRY, ORGANIC Asian Journal of Organic Chemistry Pub Date : 2024-10-01 DOI:10.1002/ajoc.202400182
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引用次数: 0

摘要

将疏水性药物封装到多糖载体中可提高其水溶性、生物相容性、肿瘤特异性蓄积和治疗效果。本研究通过酰胺缩合反应将苯硼酸(PBA)锚定在生物相容性多糖透明质酸(HA)的链上,从而制备出刺激响应型靶向给药系统。通过硼酸盐交联 PBA 与卡培他滨(CAPE)和阿糖胞苷(Al)等含二元醇的抗癌药物,制备了一系列由疏水性药物核心和亲水性透明质酸外壳组成的 pH 响应型共轭透明质酸纳米粒子。通过使用这种多糖载体,在酸性 pH 条件下实现了令人满意的靶向药物释放行为,降低了细胞毒性,提高了抗癌效果。相信这一策略在多糖改性和抗癌相关应用方面具有巨大潜力。
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Phenylboronic Acid‐Functionalized Hyaluronic Acid as Polysaccharide Carriers for Diol‐Containing Drugs Delivery
Packaging hydrophobic drugs into polysaccharide carriers can improve their aqueous solubility, biocompatibility, tumor‐specific accumulation, and therapeutic effect. In this work, phenylboronic acid (PBA) was anchored onto the chain of biocompatible polysaccharide hyaluronic acid (HA) by an amide condensation reaction, which could be used to fabricate stimuli‐responsive targeted drug delivery systems. A series of pH‐responsive conjugated hyaluronic acid nanoparticles composed of a hydrophobic drug core and hydrophilic hyaluronic acid shell were prepared by the boronate‐crosslink of the PBA with diol‐containing anticancer drugs such as capecitabine (CAPE) and aloin (Al). Satisfactory targeted drug release behavior at acidic pH, lower cytotoxicity, and higher anticancer effect were realized by using this polysaccharide carrier. It is believed that this strategy has great potential for polysaccharide modification and anticancer‐associated applications.
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来源期刊
CiteScore
4.70
自引率
3.70%
发文量
372
期刊介绍: Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
期刊最新文献
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