{"title":"探索沉积在带电晕的多孔复合聚乳酸/聚(ε-己内酯)基底上的聚电解质多层膜，用于增强药物输送系统","authors":"Temenuzhka Yovcheva;Asya Viraneva;Maria Marudova;Aleksandar Grigorov","doi":"10.1109/TDEI.2024.3423050","DOIUrl":null,"url":null,"abstract":"Polyelectrolyte multilayers (PEMs) deposited on porous composite poly-lactic acid (PDLA)/poly(\n<inline-formula> <tex-math>$\\varepsilon $ </tex-math></inline-formula>\n-caprolactone) (PEC) substrates are investigated. The substrates are charged with a corona discharge. The dependence of the normalized surface potentials on the storage time of the charged substrates is studied. Layer-by-layer (LbL) technique enables multilayer deposition on the substrates. A model drug Benzydamine hydrochloride (Benz) is loaded into the chitosan layers. A study of the drug release kinetics in saline buffer is carried out and the amount released is quantified spectrophotometrically.","PeriodicalId":13247,"journal":{"name":"IEEE Transactions on Dielectrics and Electrical Insulation","volume":"31 5","pages":"2330-2334"},"PeriodicalIF":2.9000,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring Polyelectrolyte Multilayers Deposited on Corona-Charged Porous Composite Polylactic Acid/Poly(ε-Caprolactone) Substrates for Enhanced Drug Delivery Systems\",\"authors\":\"Temenuzhka Yovcheva;Asya Viraneva;Maria Marudova;Aleksandar Grigorov\",\"doi\":\"10.1109/TDEI.2024.3423050\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Polyelectrolyte multilayers (PEMs) deposited on porous composite poly-lactic acid (PDLA)/poly(\\n<inline-formula> <tex-math>$\\\\varepsilon $ </tex-math></inline-formula>\\n-caprolactone) (PEC) substrates are investigated. The substrates are charged with a corona discharge. The dependence of the normalized surface potentials on the storage time of the charged substrates is studied. Layer-by-layer (LbL) technique enables multilayer deposition on the substrates. A model drug Benzydamine hydrochloride (Benz) is loaded into the chitosan layers. A study of the drug release kinetics in saline buffer is carried out and the amount released is quantified spectrophotometrically.\",\"PeriodicalId\":13247,\"journal\":{\"name\":\"IEEE Transactions on Dielectrics and Electrical Insulation\",\"volume\":\"31 5\",\"pages\":\"2330-2334\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-07-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IEEE Transactions on Dielectrics and Electrical Insulation\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://ieeexplore.ieee.org/document/10587028/\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE Transactions on Dielectrics and Electrical Insulation","FirstCategoryId":"5","ListUrlMain":"https://ieeexplore.ieee.org/document/10587028/","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
Exploring Polyelectrolyte Multilayers Deposited on Corona-Charged Porous Composite Polylactic Acid/Poly(ε-Caprolactone) Substrates for Enhanced Drug Delivery Systems
Polyelectrolyte multilayers (PEMs) deposited on porous composite poly-lactic acid (PDLA)/poly(
$\varepsilon $
-caprolactone) (PEC) substrates are investigated. The substrates are charged with a corona discharge. The dependence of the normalized surface potentials on the storage time of the charged substrates is studied. Layer-by-layer (LbL) technique enables multilayer deposition on the substrates. A model drug Benzydamine hydrochloride (Benz) is loaded into the chitosan layers. A study of the drug release kinetics in saline buffer is carried out and the amount released is quantified spectrophotometrically.
期刊介绍：
Topics that are concerned with dielectric phenomena and measurements, with development and characterization of gaseous, vacuum, liquid and solid electrical insulating materials and systems; and with utilization of these materials in circuits and systems under condition of use.
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