宁乡猪源性平肠球菌 HNAU0516 通过促进仔猪肠道健康和调节肠道微生物群改善断奶后腹泻症状

IF 4 2区 农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE Animal Pub Date : 2024-09-01 DOI:10.1016/j.animal.2024.101220
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引用次数: 0

摘要

早期断奶引起的应激会导致腹泻,严重影响仔猪的生长性能。造成断奶后腹泻的一个关键因素是肠道细菌菌群失调。作为一种很有前景的益生菌,氨糖对肠道健康的影响和机制尚不明确。在本研究中,我们探讨了口服补充宁乡猪源性 HNAU0516 对仔猪肠道细菌群落、免疫应答和肠道屏障功能的影响及其潜在机制。将体重相近的 21 日龄杜洛克×(兰德赛×约克夏)仔猪随机分为两组。HNAU0516 给药组在整个试验期间口服宁乡猪源性 HNAU0516。相反,对照组则接受相同剂量的生理盐水。我们的研究结果表明,添加 HNAU0516 能有效降低仔猪腹泻率 ( = 0.010)。值得注意的是,这种益生菌能促进肠道发育,增强肠道屏障功能。它还具有潜在的抗炎特性。此外,补充 HNAU0516 能显著重塑结肠微生物群,并增加醋酸盐的产量 ( = 0.007)。总之,我们的研究强调,宁乡猪源性 HNAU0516 可通过促进肠道发育、增强肠道屏障功能、降低肠道通透性、调节肠道微生物群和增加短链脂肪酸的产生来改善断奶后腹泻。
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Ningxiang pig-derived Enterococcus hirae HNAU0516 ameliorates postweaning diarrhoea by promoting intestinal health and modulating the gut microbiota in piglets

Early weaning-induced stress precipitates diarrhoea, significantly curtailing the growth performance of piglets. A pivotal contributor to this postweaning affliction is the emergence of gut bacterial dysbiosis. Enterococcus hirae, a promising probiotic, has indicated unclear effects and mechanisms on intestinal health. In this study, we investigated the effects and underlying mechanisms of oral supplementation with Ningxiang pig-derived Enterococcus hirae HNAU0516 orally supplementation on the gut bacterial community, immune response and gut barrier function in piglets. 21 d age Duroc × (Landrace × Yorkshire) piglets with a similar BW were randomly allocated to two groups. The Enterococcus hirae HNAU0516 administration group was inoculated orally with Ningxiang pig-derived Enterococcus hirae HNAU0516 throughout the trial period. Conversely, the control group received the same volume of physiological saline. Our findings revealed that Enterococcus hirae HNAU0516 supplementation effectively reduced diarrhoea rates of piglets (P = 0.010). Notably, this probiotic promoted intestinal development and enhanced intestinal barrier function. It also showed potential anti-inflammatory properties. Furthermore, Enterococcus hirae HNAU0516 supplementation significantly remodelled the colonic microbiota and increased the production of acetate (P = 0.007). In conclusion, our study highlights that Ningxiang pig-derived Enterococcus hirae HNAU0516 improves postweaning diarrhoea by promoting intestinal development, enhancing intestinal barrier function, decreasing intestinal permeability, modulating intestinal microbiota, and increasing short-chain fatty acids production.

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来源期刊
Animal
Animal 农林科学-奶制品与动物科学
CiteScore
7.50
自引率
2.80%
发文量
246
审稿时长
3 months
期刊介绍: Editorial board animal attracts the best research in animal biology and animal systems from across the spectrum of the agricultural, biomedical, and environmental sciences. It is the central element in an exciting collaboration between the British Society of Animal Science (BSAS), Institut National de la Recherche Agronomique (INRA) and the European Federation of Animal Science (EAAP) and represents a merging of three scientific journals: Animal Science; Animal Research; Reproduction, Nutrition, Development. animal publishes original cutting-edge research, ''hot'' topics and horizon-scanning reviews on animal-related aspects of the life sciences at the molecular, cellular, organ, whole animal and production system levels. The main subject areas include: breeding and genetics; nutrition; physiology and functional biology of systems; behaviour, health and welfare; farming systems, environmental impact and climate change; product quality, human health and well-being. Animal models and papers dealing with the integration of research between these topics and their impact on the environment and people are particularly welcome.
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