P-147 HEMOLYMPHOEPOIETIC CANCER AND OCCUPATIONAL EXPOSURE: PROPORTIONAL MORTALITY RATIO STRATIFIED BY PERMANENCE IN THE OCCUPATIONAL SECTOR

Introduction Blood and lymphatic tumors represent about 7% of all new cancer diagnoses in Italy. The occupational component plays an important role in their etiology. Objective The goal of the study is to assess the excess risk of hemolymphoepoietic cancer in occupational sectors and how it varies in terms of working days in a specific area of employment. Methods The Italian national statistical institute archive of the causes of death for the years 2005 – 2018 has been integrated with the National Social Insurance Agency contribution archives, referring only to the private sector starting from the 1974 for analysing the occupational history of deceased. The Proportional Mortality Ratio (PMR) was calculated by specific cause and sector considering the services sector as the reference. Age-adjusted PMRs were estimated using a generalized linear model (GLM) with a logarithmic link function. The 95% confidence interval was calculated for estimated risks. The analysis was implemented by stratifying by classes of permanence in the sector defined based on days of contributions. Results The dataset contains 25,883 males from 45 occupational sectors. Excess risk of myeloma is observed for the highest class of permanence in the mechanical engineering, mining, metals, iron, and steel industries. A positive trend in the excess risk of lymphoma was observed in the chemical, leather, wood, and printing sector; and of leukaemia in the health and veterinary service. Discussion and conclusion The substantial role of occupational risks in hemolymphoepoietic cancer is confirmed. A better understanding of the diseases etiology is essential for the prevention policies development.