{"title":"用于皮肤癌治疗的荧光配位聚合物纳米材料的合成与表征","authors":"Rui Yuan, Yaqiong Bai, Hanghang Du","doi":"10.1007/s11051-024-06064-6","DOIUrl":null,"url":null,"abstract":"<p>Skin cancer is one of the most common cancers and is on the rise globally. Prevention is the key to minimizing deaths from skin cancer. Development of effective drugs is a high priority. This study successfully synthesized two coordination polymers (CPs) with excellent fluorescence properties, designated as CP<b>1</b> and CP<b>2</b>, and characterized their structures using X-ray single crystal diffraction. Based on these findings, CP<b>1</b> and CP<b>2</b> were cross-linked with sodium alginate to load the typical drug Odomzo, forming NaAlg@<b>1</b>-Odomzo and NaAlg@<b>2</b>-Odomzo. This design not only increased the encapsulation efficiency of Odomzo but also enhanced its biocompatibility. The physicochemical structure of the new systems was extensively characterized using Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and thermogravimetric analysis (TGA). Subsequently, a series of biological experiments were conducted to evaluate the potential value of the new systems in cancer treatment. Treatment of skin cancer cells with the systems significantly inhibited their proliferation. To further explore the potential therapeutic mechanism, we examined the expression levels of CCND1. The results showed that CCND1 expression was significantly downregulated after systems treatment. Both drug delivery systems were able to inhibit the proliferation of skin cancer cells by downregulating the expression of CCND1.</p>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis and characterization of nanomaterials constructed from fluorescent coordination polymers for skin cancer therapy\",\"authors\":\"Rui Yuan, Yaqiong Bai, Hanghang Du\",\"doi\":\"10.1007/s11051-024-06064-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Skin cancer is one of the most common cancers and is on the rise globally. Prevention is the key to minimizing deaths from skin cancer. Development of effective drugs is a high priority. This study successfully synthesized two coordination polymers (CPs) with excellent fluorescence properties, designated as CP<b>1</b> and CP<b>2</b>, and characterized their structures using X-ray single crystal diffraction. Based on these findings, CP<b>1</b> and CP<b>2</b> were cross-linked with sodium alginate to load the typical drug Odomzo, forming NaAlg@<b>1</b>-Odomzo and NaAlg@<b>2</b>-Odomzo. This design not only increased the encapsulation efficiency of Odomzo but also enhanced its biocompatibility. The physicochemical structure of the new systems was extensively characterized using Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and thermogravimetric analysis (TGA). Subsequently, a series of biological experiments were conducted to evaluate the potential value of the new systems in cancer treatment. Treatment of skin cancer cells with the systems significantly inhibited their proliferation. To further explore the potential therapeutic mechanism, we examined the expression levels of CCND1. The results showed that CCND1 expression was significantly downregulated after systems treatment. Both drug delivery systems were able to inhibit the proliferation of skin cancer cells by downregulating the expression of CCND1.</p>\",\"PeriodicalId\":653,\"journal\":{\"name\":\"Journal of Nanoparticle Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-07-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Nanoparticle Research\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1007/s11051-024-06064-6\",\"RegionNum\":4,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nanoparticle Research","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1007/s11051-024-06064-6","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Synthesis and characterization of nanomaterials constructed from fluorescent coordination polymers for skin cancer therapy
Skin cancer is one of the most common cancers and is on the rise globally. Prevention is the key to minimizing deaths from skin cancer. Development of effective drugs is a high priority. This study successfully synthesized two coordination polymers (CPs) with excellent fluorescence properties, designated as CP1 and CP2, and characterized their structures using X-ray single crystal diffraction. Based on these findings, CP1 and CP2 were cross-linked with sodium alginate to load the typical drug Odomzo, forming NaAlg@1-Odomzo and NaAlg@2-Odomzo. This design not only increased the encapsulation efficiency of Odomzo but also enhanced its biocompatibility. The physicochemical structure of the new systems was extensively characterized using Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and thermogravimetric analysis (TGA). Subsequently, a series of biological experiments were conducted to evaluate the potential value of the new systems in cancer treatment. Treatment of skin cancer cells with the systems significantly inhibited their proliferation. To further explore the potential therapeutic mechanism, we examined the expression levels of CCND1. The results showed that CCND1 expression was significantly downregulated after systems treatment. Both drug delivery systems were able to inhibit the proliferation of skin cancer cells by downregulating the expression of CCND1.
期刊介绍:
The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size.
Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology.
The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.