儿童抗中性粒细胞胞浆自身抗体血管炎的最新进展。

IF 5.2 2区 医学 Q1 RHEUMATOLOGY Current opinion in rheumatology Pub Date : 2024-09-01 Epub Date: 2024-07-10 DOI:10.1097/BOR.0000000000001033
Jessica L Bloom, Eveline Y Wu
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引用次数: 0

摘要

综述目的:抗中性粒细胞胞浆自身抗体(ANCA)相关性血管炎(AAV)通常会危及儿童的器官或生命,并在儿童心理和身体发育的重要时期对其造成影响。本综述涵盖了儿童 AAV 的病理生理学、诊断、管理和预后方面的最新进展,并强调了对资金和加强研究合作的持续需求:最新研究结果:最近的研究工作增进了我们对儿童艾滋病病毒疾病发病机制的了解,并有可能确定新的生物标志物和治疗靶点。临床合作研究也强调了儿童的不同表现,并确定了与较差预后相关的潜在因素。基于共识的治疗指南也已出现,但临床试验对于更好地了解 AAV 患儿的治疗效果和安全性仍然至关重要。新的、经过验证的结果测量方法,包括那些由患者报告的方法,将促进这些急需的儿科 AAV 临床试验。
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Update on antineutrophil cytoplasmic autoantibody vasculitis in children.

Purpose of review: Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is often organ- or life-threatening in children and impacts them during important periods of psychosocial and physical development. This review covers recent advances in the pathophysiology, diagnosis, management, and outcomes of AAV in children and highlights the ongoing need for funding and increased research collaboration.

Recent findings: Recent work has improved our understanding of AAV disease pathogenesis, potentially identifying new biomarkers and therapeutic targets. Collaborative clinical studies have also highlighted the variable manifestations in children and identified potential factors associated with poorer outcomes. Consensus-based treatment guidelines are also appearing, but clinical trials are still essential to better understanding treatment efficacy and safety in children affected by AAV. New, validated outcome measures, including those that are patient-reported, will facilitate these much-needed clinical trials in pediatric AAV.

Summary: There is a continued need for more rigorous study in pediatric AAV, however, there is certainly excitement with the increase in recent research relevant to the pediatric population.

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来源期刊
Current opinion in rheumatology
Current opinion in rheumatology 医学-风湿病学
CiteScore
9.70
自引率
2.00%
发文量
89
审稿时长
6-12 weeks
期刊介绍: A high impact review journal which boasts an international readership, Current Opinion in Rheumatology offers a broad-based perspective on the most recent and exciting developments within the field of rheumatology. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include vasculitis syndromes, medical physiology and rheumatic diseases, crystal deposition diseases and rheumatoid arthritis. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.
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