小非编码 RNA 与胰腺导管腺癌:诊断、发病机制、耐药性和治疗潜力之间的联系。

IF 9.7 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-07-08 DOI:10.1016/j.bbcan.2024.189153
Ryan N. Fuller , Ann Morcos , Joab Galvan Bustillos , David Caba Molina , Nathan R. Wall
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引用次数: 0

摘要

本综述全面研究了小非编码 RNA(sncRNA)与胰腺导管腺癌(PDAC)之间错综复杂的相互作用。我们的分析揭示了 sncRNA 在 PDAC 生物学各方面的关键作用,包括诊断、发病机制、耐药性和治疗策略。sncRNA 已成为 PDAC 有希望的生物标记物,在患病组织中显示出独特的表达谱。sncRNA 的差异表达模式通常可在体液中检测到,为早期和微创诊断方法提供了潜力。此外,sncRNA 在 PDAC 发病机制中表现出复杂的参与性,可调节增殖、凋亡和转移等关键细胞过程。此外,对 sncRNA 介导的致病途径的机理研究也为新的治疗靶点和干预措施提供了启示。本综述的一个重点是揭示 PDAC 耐药的 sncRNA 机制。从分子水平了解这些机制对于制定克服耐药性的策略至关重要。在探讨治疗前景时,我们讨论了 sncRNA 本身作为治疗药物的潜力,因为 sncRNA 具有高度特异性调节基因表达的能力,使其成为有吸引力的候选靶向治疗药物。总之,这篇综述整合了目前有关 PDAC 中 sncRNAs 的知识,从整体角度探讨了它们在诊断、致病和治疗方面的相关性。通过阐明 sncRNAs 在 PDAC 生物学中的作用,本综述为开发新型诊断工具和靶向治疗方法提供了宝贵的见解,这对改善 PDAC 患者的预后至关重要。
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Small non-coding RNAs and pancreatic ductal adenocarcinoma: Linking diagnosis, pathogenesis, drug resistance, and therapeutic potential

This review comprehensively investigates the intricate interplay between small non-coding RNAs (sncRNAs) and pancreatic ductal adenocarcinoma (PDAC), a devastating malignancy with limited therapeutic options. Our analysis reveals the pivotal roles of sncRNAs in various facets of PDAC biology, spanning diagnosis, pathogenesis, drug resistance, and therapeutic strategies. sncRNAs have emerged as promising biomarkers for PDAC, demonstrating distinct expression profiles in diseased tissues. sncRNA differential expression patterns, often detectable in bodily fluids, hold potential for early and minimally invasive diagnostic approaches. Furthermore, sncRNAs exhibit intricate involvement in PDAC pathogenesis, regulating critical cellular processes such as proliferation, apoptosis, and metastasis. Additionally, mechanistic insights into sncRNA-mediated pathogenic pathways illuminate novel therapeutic targets and interventions. A significant focus of this review is dedicated to unraveling sncRNA mechanisms underlying drug resistance in PDAC. Understanding these mechanisms at the molecular level is imperative for devising strategies to overcome drug resistance. Exploring the therapeutic landscape, we discuss the potential of sncRNAs as therapeutic agents themselves as their ability to modulate gene expression with high specificity renders them attractive candidates for targeted therapy. In summary, this review integrates current knowledge on sncRNAs in PDAC, offering a holistic perspective on their diagnostic, pathogenic, and therapeutic relevance. By elucidating the roles of sncRNAs in PDAC biology, this review provides valuable insights for the development of novel diagnostic tools and targeted therapeutic approaches, crucial for improving the prognosis of PDAC patients.

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来源期刊
Biochimica et biophysica acta. Reviews on cancer
Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学
CiteScore
17.20
自引率
0.00%
发文量
138
审稿时长
33 days
期刊介绍: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.
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