{"title":"北印度儿童中的尤文肉瘤:人口统计学、结果和预后因素","authors":"Gitika Pant , Nishant Verma , Vinay Shukla","doi":"10.1016/j.cegh.2024.101708","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Ewings sarcoma is relatively rare and accounts for a 3–4% of childhood cancer. The data of Ewings sarcoma is scarce in North India and so the study was planned to find out the demographics, outcome and prognostic factors of Ewings sarcoma.</p></div><div><h3>Methods</h3><p>This is a retrospective study conducted in the Department of Pediatrics, Pediatric Oncology unit at a tertiary care centre (KGMC, Lucknow) in North India. All patients of age 1–16 years with biopsy and IHC proven Ewings sarcoma during 2015–2020 were included in the study. Parameters were noted and follow up was done till December 2021. Statistical analysis was done by Microsoft Excel and GraphPad Prism 10. Overall survival was assessed using Kaplan Meir Survival Analysis. P value < 0.05 was considered significant.</p></div><div><h3>Results</h3><p>75 patients i.e.4.1 % of the total were diagnosed with ES. Median age of patients was 10 years. 37.35 % had metastasis at presentation. 32 % were defaulters (abandoned and not taking treatment). Extremity ES constituted 46.7 % of the patient. 29.4 % patients relapsed. The overall survival of the whole cohort was 23.5 % and OS of localised disease was 42.3 %. OS of patients with respect to various sites failed to show any significance. Staging of disease have shown to be affecting outcome.</p></div><div><h3>Conclusion</h3><p>Proportion of Ewings sarcoma was in accordance with the world's data but the survival outcome was low at our centre primarily due to delayed presentation translating to metastatic disease at diagnosis and abandonment issues along with defaults in treatment. Conducting focussed group discussions, awareness sessions, caregivers counselling and educating them about disease might help in curbing these factors.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002045/pdfft?md5=cf6c9774b0251df14682c1a7e4f7218a&pid=1-s2.0-S2213398424002045-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Ewings sarcoma in pediatric population of North India: Demographics, outcome & prognostic factors\",\"authors\":\"Gitika Pant , Nishant Verma , Vinay Shukla\",\"doi\":\"10.1016/j.cegh.2024.101708\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Ewings sarcoma is relatively rare and accounts for a 3–4% of childhood cancer. The data of Ewings sarcoma is scarce in North India and so the study was planned to find out the demographics, outcome and prognostic factors of Ewings sarcoma.</p></div><div><h3>Methods</h3><p>This is a retrospective study conducted in the Department of Pediatrics, Pediatric Oncology unit at a tertiary care centre (KGMC, Lucknow) in North India. All patients of age 1–16 years with biopsy and IHC proven Ewings sarcoma during 2015–2020 were included in the study. Parameters were noted and follow up was done till December 2021. Statistical analysis was done by Microsoft Excel and GraphPad Prism 10. Overall survival was assessed using Kaplan Meir Survival Analysis. P value < 0.05 was considered significant.</p></div><div><h3>Results</h3><p>75 patients i.e.4.1 % of the total were diagnosed with ES. Median age of patients was 10 years. 37.35 % had metastasis at presentation. 32 % were defaulters (abandoned and not taking treatment). Extremity ES constituted 46.7 % of the patient. 29.4 % patients relapsed. The overall survival of the whole cohort was 23.5 % and OS of localised disease was 42.3 %. OS of patients with respect to various sites failed to show any significance. Staging of disease have shown to be affecting outcome.</p></div><div><h3>Conclusion</h3><p>Proportion of Ewings sarcoma was in accordance with the world's data but the survival outcome was low at our centre primarily due to delayed presentation translating to metastatic disease at diagnosis and abandonment issues along with defaults in treatment. Conducting focussed group discussions, awareness sessions, caregivers counselling and educating them about disease might help in curbing these factors.</p></div>\",\"PeriodicalId\":46404,\"journal\":{\"name\":\"Clinical Epidemiology and Global Health\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2213398424002045/pdfft?md5=cf6c9774b0251df14682c1a7e4f7218a&pid=1-s2.0-S2213398424002045-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Epidemiology and Global Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2213398424002045\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Epidemiology and Global Health","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213398424002045","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 0
摘要
背景Ewings肉瘤相对罕见,占儿童癌症的3-4%。在北印度,Ewings 肉瘤的数据非常稀少,因此计划开展这项研究,以了解 Ewings 肉瘤的人口统计学、结果和预后因素。研究纳入了 2015-2020 年期间所有经活检和 IHC 证实为 Ewings 肉瘤的 1-16 岁患者。研究人员记录了各项参数,并对其进行了随访,直至 2021 年 12 月。统计分析采用 Microsoft Excel 和 GraphPad Prism 10 进行。采用 Kaplan Meir 生存分析评估总生存率。结果 75 名患者被确诊为 ES,占总人数的 4.1%。患者的中位年龄为 10 岁。37.35%的患者在就诊时已出现转移。32%的患者为失约者(放弃治疗且未接受治疗)。肢端 ES 患者占 46.7%。29.4%的患者复发。整个组群的总生存率为 23.5%,局部疾病的 OS 为 42.3%。不同部位患者的生存率差异不大。结论Ewings肉瘤的发病比例与世界数据相符,但我们中心的存活率较低,主要原因是患者在确诊时已转化为转移性疾病,导致延迟就诊和放弃治疗。开展有针对性的小组讨论、提高认识会议、护理人员咨询和疾病教育可能有助于遏制这些因素。
Ewings sarcoma in pediatric population of North India: Demographics, outcome & prognostic factors
Background
Ewings sarcoma is relatively rare and accounts for a 3–4% of childhood cancer. The data of Ewings sarcoma is scarce in North India and so the study was planned to find out the demographics, outcome and prognostic factors of Ewings sarcoma.
Methods
This is a retrospective study conducted in the Department of Pediatrics, Pediatric Oncology unit at a tertiary care centre (KGMC, Lucknow) in North India. All patients of age 1–16 years with biopsy and IHC proven Ewings sarcoma during 2015–2020 were included in the study. Parameters were noted and follow up was done till December 2021. Statistical analysis was done by Microsoft Excel and GraphPad Prism 10. Overall survival was assessed using Kaplan Meir Survival Analysis. P value < 0.05 was considered significant.
Results
75 patients i.e.4.1 % of the total were diagnosed with ES. Median age of patients was 10 years. 37.35 % had metastasis at presentation. 32 % were defaulters (abandoned and not taking treatment). Extremity ES constituted 46.7 % of the patient. 29.4 % patients relapsed. The overall survival of the whole cohort was 23.5 % and OS of localised disease was 42.3 %. OS of patients with respect to various sites failed to show any significance. Staging of disease have shown to be affecting outcome.
Conclusion
Proportion of Ewings sarcoma was in accordance with the world's data but the survival outcome was low at our centre primarily due to delayed presentation translating to metastatic disease at diagnosis and abandonment issues along with defaults in treatment. Conducting focussed group discussions, awareness sessions, caregivers counselling and educating them about disease might help in curbing these factors.
期刊介绍:
Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.