通过纳米层析诱导的巨细胞吞噬作用增强细胞摄取能力（Adv. Funct. Mater. 28/2024）

IF 18.5 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Advanced Functional Materials Pub Date : 2024-07-10 DOI:10.1002/adfm.202470153

Morteza Aramesh, Di Yu, Magnus Essand, Cecilia Persson

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摘要

纳米形貌诱导的巨细胞吞噬作用在文章编号 2400487 中，Morteza Aramesh 及其合作者研究了来自纳米多孔表面的纳米形貌线索如何影响细胞的摄取效率。研究结果表明，当细胞暴露在纳米多孔表面时，细胞对一系列载体的摄取效率明显提高。摄取过程取决于纳米孔的大小和形态，当盲孔大小为 400 纳米时，摄取效率达到峰值。在纳米多孔表面上观察到多种载体的基因转导增强，包括慢病毒、杆状病毒和 mRNA 分子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Enhanced Cellular Uptake through Nanotopography-Induced Macropinocytosis (Adv. Funct. Mater. 28/2024)

Nanotopography-Induced Macropinocytosis

In article number 2400487, Morteza Aramesh and co-workers investigate how nanotopographical cues from nanoporous surfaces impact the uptake efficiency by cells. The results demonstrate notable enhancements in cellular uptake efficiency across a range of vectors when cells are exposed to nanoporous surfaces. The uptake process is found to be dependent on the size and morphology of the nanopores, reaching a peak efficacy with blind pores of 400 nm in size. Enhanced genetic transduction on nanoporous surfaces are observed for multiple vectors, including lentiviruses, baculoviruses, and mRNA molecules.

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来源期刊

Advanced Functional Materials 工程技术-材料科学：综合

CiteScore

29.50

自引率

4.20%

发文量

2086

审稿时长

2.1 months

期刊介绍： Firmly established as a top-tier materials science journal, Advanced Functional Materials reports breakthrough research in all aspects of materials science, including nanotechnology, chemistry, physics, and biology every week. Advanced Functional Materials is known for its rapid and fair peer review, quality content, and high impact, making it the first choice of the international materials science community.