Miao Hu, Yanfen Ma, Keli Jia, SaSa Liu, Huarong Jing, Ruicheng Li
{"title":"分析371名新确诊多发性骨髓瘤患者的凝血改变及其与β2-微球蛋白的相关性。","authors":"Miao Hu, Yanfen Ma, Keli Jia, SaSa Liu, Huarong Jing, Ruicheng Li","doi":"10.1080/16078454.2024.2377849","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To explore the changes in the coagulation function of patients newly diagnosed with multiple myeloma (MM) at different stages and with different M protein types, and to analyze the correlation between coagulation indexes and β2-microglobulin (β2-MG).</p><p><strong>Methods: </strong>A total of 371 Patients with newly diagnosed MM (<i>n </i>= 371) and healthy controls (<i>n </i>= 48) were selected from January 2016 to December 2022. Baseline data, β2-MG and coagulation index values were collected. Indexes included prothrombin time (PT), activated partial thromboplastin time (APPT), fibrinogen (FIB), thrombin time (TT), fibrinogen degradation products (FDP), and D-dimer(D-D). Patients were divided into different groups according to the Durie-Salmon staging system (DS), the International Staging System (ISS) and disease classification (M protein type). The levels of these six indexes were compared among the groups and the correlation between each index and β2-MG was analyzed.</p><p><strong>Results: </strong>Compared to the normal control group, the levels of PT, FIB, TT, FDP and D-D in the MM group were significantly higher (all <i>P </i>< 0.001). As DS and ISS staging increased, the levels of PT, TT, FDP and D-D also increased significantly (all <i>P </i>< 0.001). β2-MG was positively correlated with PT, TT, and FDP levels (Spearman <i>r </i>= 0.157, 0.270, 0.108, respectively; all <i>P </i>< 0.05), and negatively correlated with FIB (<i>r</i> = -0.220, <i>P </i>< 0.001). Significant differences existed in the levels of these six indexes among different M protein types (all <i>P </i>< 0.001). Among them, PT and APTT increased significantly in the IgA-κ group, FIB increased in the λ light chain group, TT increased in the IgG-κ group, FDP increased in the κ light chain group, and D-D increased in the IgG-λ group.</p><p><strong>Conclusions: </strong>The degree of coagulation dysfunction in MM patients increases with disease stage and abnormal increases of various coagulation indicators occur in different M protein types and are closely related to β2-MG.</p>","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"29 1","pages":"2377849"},"PeriodicalIF":2.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Analysis of coagulation alteration and its correlation with β2-microglobulin in 371 patients with newly diagnosed multiple myeloma.\",\"authors\":\"Miao Hu, Yanfen Ma, Keli Jia, SaSa Liu, Huarong Jing, Ruicheng Li\",\"doi\":\"10.1080/16078454.2024.2377849\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>To explore the changes in the coagulation function of patients newly diagnosed with multiple myeloma (MM) at different stages and with different M protein types, and to analyze the correlation between coagulation indexes and β2-microglobulin (β2-MG).</p><p><strong>Methods: </strong>A total of 371 Patients with newly diagnosed MM (<i>n </i>= 371) and healthy controls (<i>n </i>= 48) were selected from January 2016 to December 2022. Baseline data, β2-MG and coagulation index values were collected. Indexes included prothrombin time (PT), activated partial thromboplastin time (APPT), fibrinogen (FIB), thrombin time (TT), fibrinogen degradation products (FDP), and D-dimer(D-D). Patients were divided into different groups according to the Durie-Salmon staging system (DS), the International Staging System (ISS) and disease classification (M protein type). The levels of these six indexes were compared among the groups and the correlation between each index and β2-MG was analyzed.</p><p><strong>Results: </strong>Compared to the normal control group, the levels of PT, FIB, TT, FDP and D-D in the MM group were significantly higher (all <i>P </i>< 0.001). As DS and ISS staging increased, the levels of PT, TT, FDP and D-D also increased significantly (all <i>P </i>< 0.001). β2-MG was positively correlated with PT, TT, and FDP levels (Spearman <i>r </i>= 0.157, 0.270, 0.108, respectively; all <i>P </i>< 0.05), and negatively correlated with FIB (<i>r</i> = -0.220, <i>P </i>< 0.001). Significant differences existed in the levels of these six indexes among different M protein types (all <i>P </i>< 0.001). Among them, PT and APTT increased significantly in the IgA-κ group, FIB increased in the λ light chain group, TT increased in the IgG-κ group, FDP increased in the κ light chain group, and D-D increased in the IgG-λ group.</p><p><strong>Conclusions: </strong>The degree of coagulation dysfunction in MM patients increases with disease stage and abnormal increases of various coagulation indicators occur in different M protein types and are closely related to β2-MG.</p>\",\"PeriodicalId\":13161,\"journal\":{\"name\":\"Hematology\",\"volume\":\"29 1\",\"pages\":\"2377849\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2024-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Hematology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/16078454.2024.2377849\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/7/12 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hematology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/16078454.2024.2377849","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/12 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
研究目的探讨新诊断的多发性骨髓瘤(MM)患者在不同阶段、不同M蛋白类型的凝血功能变化,分析凝血指标与β2-微球蛋白(β2-MG)的相关性:方法:选取2016年1月至2022年12月期间新确诊的371例MM患者(n = 371)和健康对照组(n = 48)。收集基线数据、β2-MG 和凝血指标值。指标包括凝血酶原时间(PT)、活化部分凝血活酶时间(APPT)、纤维蛋白原(FIB)、凝血酶时间(TT)、纤维蛋白原降解产物(FDP)和D-二聚体(D-D)。根据杜里-萨尔蒙分期系统(DS)、国际分期系统(ISS)和疾病分类(M 蛋白类型)将患者分为不同的组别。比较了各组的这六项指标水平,并分析了各项指标与β2-MG之间的相关性:结果:与正常对照组相比,MM 组的 PT、FIB、TT、FDP、D-D 水平明显升高(均 P P r = 0.157、0.270、0.108;均 P r = -0.220,P P 结论:MM 组的凝血功能障碍程度明显高于正常对照组:MM患者的凝血功能障碍程度随疾病分期而加重,不同M蛋白类型的患者各种凝血指标均出现异常升高,且与β2-MG密切相关。
Analysis of coagulation alteration and its correlation with β2-microglobulin in 371 patients with newly diagnosed multiple myeloma.
Objectives: To explore the changes in the coagulation function of patients newly diagnosed with multiple myeloma (MM) at different stages and with different M protein types, and to analyze the correlation between coagulation indexes and β2-microglobulin (β2-MG).
Methods: A total of 371 Patients with newly diagnosed MM (n = 371) and healthy controls (n = 48) were selected from January 2016 to December 2022. Baseline data, β2-MG and coagulation index values were collected. Indexes included prothrombin time (PT), activated partial thromboplastin time (APPT), fibrinogen (FIB), thrombin time (TT), fibrinogen degradation products (FDP), and D-dimer(D-D). Patients were divided into different groups according to the Durie-Salmon staging system (DS), the International Staging System (ISS) and disease classification (M protein type). The levels of these six indexes were compared among the groups and the correlation between each index and β2-MG was analyzed.
Results: Compared to the normal control group, the levels of PT, FIB, TT, FDP and D-D in the MM group were significantly higher (all P < 0.001). As DS and ISS staging increased, the levels of PT, TT, FDP and D-D also increased significantly (all P < 0.001). β2-MG was positively correlated with PT, TT, and FDP levels (Spearman r = 0.157, 0.270, 0.108, respectively; all P < 0.05), and negatively correlated with FIB (r = -0.220, P < 0.001). Significant differences existed in the levels of these six indexes among different M protein types (all P < 0.001). Among them, PT and APTT increased significantly in the IgA-κ group, FIB increased in the λ light chain group, TT increased in the IgG-κ group, FDP increased in the κ light chain group, and D-D increased in the IgG-λ group.
Conclusions: The degree of coagulation dysfunction in MM patients increases with disease stage and abnormal increases of various coagulation indicators occur in different M protein types and are closely related to β2-MG.
期刊介绍:
Hematology is an international journal publishing original and review articles in the field of general hematology, including oncology, pathology, biology, clinical research and epidemiology. Of the fixed sections, annotations are accepted on any general or scientific field: technical annotations covering current laboratory practice in general hematology, blood transfusion and clinical trials, and current clinical practice reviews the consensus driven areas of care and management.