基于肿瘤微环境的多功能纳米给药系统的构建与协同抗肿瘤研究

IF 3.9 2区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of photochemistry and photobiology. B, Biology Pub Date : 2024-07-03 DOI:10.1016/j.jphotobiol.2024.112977
Baoqing Liu , Qinghua Zheng , Xiandong Shi , Jian Shen , Ruyan Li , Jiahong Zhou
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引用次数: 0

摘要

为了解决金丝桃素(Hyp)和替拉帕唑胺(TPZ)在临床应用中存在的问题,研究人员利用介孔二氧化硅纳米颗粒(MSN)和海藻酸钠(SA)构建了一种具有协同抗肿瘤功能的纳米给药系统。该系统在肿瘤组织中表现出优异的稳定性、生理相容性和靶向药物释放性能。在体外和体内实验中,MSN 释放的 Hyp 通过光动力疗法(PDT)杀死了肿瘤细胞。肿瘤组织部位的缺氧程度加剧,使 TPZ 的抗肿瘤活性得以充分发挥。我们的研究表明,纳米给药系统各组分之间的协同效应显著提高了 Hyp 和 TPZ 的抗肿瘤特性。
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Construction and synergistic anti-tumor study of a tumor microenvironment-based multifunctional nano-drug delivery system

To solve the problems existing in the clinical application of hypericin (Hyp) and tirapazamine (TPZ), a nano-drug delivery system with synergistic anti-tumor functions was constructed using mesoporous silica nanoparticles (MSN) and sodium alginate (SA). The system exhibited excellent stability, physiological compatibility and targeted drug release performance in tumor tissues. In the in vitro and in vivo experiments, Hyp released from MSN killed tumor cells through photodynamic therapy (PDT). The degree of hypoxia in the tumor tissue site was exacerbated, enabling TPZ to fully exert its anti-tumor activity. Our studies suggested that the synergistic effects between the components of the nano-drug delivery system significantly improve the anti-tumor properties of Hyp and TPZ.

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来源期刊
CiteScore
12.10
自引率
1.90%
发文量
161
审稿时长
37 days
期刊介绍: The Journal of Photochemistry and Photobiology B: Biology provides a forum for the publication of papers relating to the various aspects of photobiology, as well as a means for communication in this multidisciplinary field. The scope includes: - Bioluminescence - Chronobiology - DNA repair - Environmental photobiology - Nanotechnology in photobiology - Photocarcinogenesis - Photochemistry of biomolecules - Photodynamic therapy - Photomedicine - Photomorphogenesis - Photomovement - Photoreception - Photosensitization - Photosynthesis - Phototechnology - Spectroscopy of biological systems - UV and visible radiation effects and vision.
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