肠外营养的兼容性和稳定性:实际考虑因素。

IF 2.1 4区 医学 Q3 NUTRITION & DIETETICS Nutrition in Clinical Practice Pub Date : 2024-10-01 Epub Date: 2024-07-12 DOI:10.1002/ncp.11189
Joseph I Boullata, Genene Salman, Jay M Mirtallo, Todd W Canada, Jessica Monczka, Kathleen M Gura, Paul Kiritsy
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引用次数: 0

摘要

肠外营养(PN)是一种复杂的制剂,包含多种成分产品,当它们作为混合物结合在一起时,会有不相容和稳定性降低的风险。在未确认兼容性和稳定性的情况下开具、配制和使用肠外营养制剂,可能会对患者造成重大伤害。不相容性或不稳定性在肉眼下很少能看出来,因此安全的 PN 混合物依赖于将所含成分的物理化学特性纳入相容性和稳定性决策。做法包括应用活性成分浓度限制,以降低不相容和不稳定的风险。本文旨在将有关 PN 兼容性和稳定性的广泛信息提炼成一个可行的蓝图,供各医疗机构用于设计和实施切实可行的措施。可将兼容性和稳定性方面的考虑因素纳入 PN 处方、医嘱审核、准备和给药等常规工作中。本综述的重点在于识别 PN 使用过程中每一步都可能发生的理化相互作用。医疗机构应将兼容性和稳定性考虑因素纳入所有参与 PN 治疗的临床医生的常规程序和实践中。这样,医疗机构中的临床医生和家庭护理人员就能安全地提供兼容性和稳定性适当的 PN 混合物。
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Parenteral nutrition compatibility and stability: Practical considerations.

Parenteral nutrition (PN) is a complex preparation that contains multiple component products with the associated risk for incompatibilities and diminished stabilities when combined together as an admixture. Significant patient harm can result from prescribing, preparing, and administering PN without confirming compatibility and stability. Incompatibility or instability is rarely obvious to the unaided eye, so safe PN admixture relies on incorporating physicochemical properties of the included components into compatibility and stability decisions. Practices include applying active ingredient concentration limits to reduce risk for incompatibilities and instabilities. The purpose of the current article is to distill the wide-ranging information on PN compatibility and stability into a feasible blueprint that individual healthcare organizations can then use to design and implement practical initiatives. Compatibility and stability considerations can be incorporated into the routine tasks of PN prescribing, order reviewing, preparing, and administering. The focus of this review is on identifying potential physicochemical interactions that can be addressed at each step in the PN use process. Organizations should incorporate compatibility and stability considerations into the routine procedures and practices of all clinicians involved with PN therapy. Those clinicians in healthcare organizations and caregivers in the home should then be in a position to safely provide the appropriate PN admixtures in terms of compatibility and stability.

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来源期刊
CiteScore
6.00
自引率
9.70%
发文量
128
审稿时长
3 months
期刊介绍: NCP is a peer-reviewed, interdisciplinary publication that publishes articles about the scientific basis and clinical application of nutrition and nutrition support. NCP contains comprehensive reviews, clinical research, case observations, and other types of papers written by experts in the field of nutrition and health care practitioners involved in the delivery of specialized nutrition support. This journal is a member of the Committee on Publication Ethics (COPE).
期刊最新文献
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